HitPredict

Interactor 1: CLOCK (O15516)
Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)
Gene: CLOCK

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0007165 - signal transduction
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 846 Hs			1 772
+	Hs
		181516 CLOCK_HUMAN (1-846): 0: 568: 100.00		TLE2_HUMAN (1-772): 4.46e-145: 445: 62.10
+	Hs
		649090 ARNT_HUMAN (5-678): 1.24e-113: 366: 18.35		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		980757 NCOA2_HUMAN (12-702): 6.74e-108: 364: 15.92		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		980925 NCOA3_HUMAN (10-825): 4.86e-85: 298: 15.61		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		980759 NCOA1_HUMAN (40-503): 1.84e-74: 267: 20.61		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		181541 CLOCK_HUMAN (1-846): 0: 568: 100.00		POC1A_HUMAN (325-603): 2.33e-51: 186: 14.59
+	Hs
		181545 CLOCK_HUMAN (1-846): 0: 568: 100.00		POC1B_HUMAN (290-512): 1.47e-23: 106: 9.78
+	Hs
		993570 NPAS1_HUMAN (32-496): 1.14e-82: 278: 16.83		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		126168 BMAL1_HUMAN (9-544): 1.35e-122: 385: 22.96		TBL1R_HUMAN (571-771): 3.06e-46: 174: 15.07
+	Hs
		126116 BMAL1_HUMAN (9-544): 1.35e-122: 385: 22.96		WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12
+	Hs
		649143 ARNT_HUMAN (5-678): 1.24e-113: 366: 18.35		SNR40_HUMAN (509-677): 5.35e-09: 60.8: 26.52
+	Mm
		985529 Q05BA5_MOUSE (43-203): 7.72e-10: 65.1: 31.21		TLE6_MOUSE (473-772): 7.97e-46: 174: 33.66