Protein: TBX5
T-box transcription factor TBX5 (T-box protein 5)

Gene: TBX5
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q99593

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001708 - cell fate specification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

916113

NKX25
Homeobox protein Nkx-2.5

2

20

Small-scale

0.825

High

1405577

BAIP2
BAR/IMD domain-containing adapter protein 2

3

0

High-throughput

0.625

High

634876

HXA5
Homeobox protein Hox-A5

1

20

High-throughput

0.618

High

1405553

TBX5
T-box transcription factor TBX5

1

13

High-throughput

0.618

High

1405561

ADNP
Activity-dependent neuroprotector homeobox protein

1

1

High-throughput

0.618

High

1405575

TBX21
T-box transcription factor TBX21

1

14

High-throughput

0.618

High

851651

GATA4
Transcription factor GATA-4

2

6

Small-scale

0.584

High

903465

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

2

14

Small-scale

0.584

High

294635

ZMY10
Zinc finger MYND domain-containing protein 10

2

0

High-throughput

0.580

High

194603

KDM6A
Lysine-specific demethylase 6A

1

3

Small-scale

0.552

High

1349754

FBX25
F-box only protein 25

1

2

Small-scale

0.501

High

862402

YAP1
Transcriptional coactivator YAP1

1

2

Small-scale

0.500

High

1371253

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.480

High

137141

MEIS1
Homeobox protein Meis1

1

12

High-throughput

0.479

High

163466

MEIS2
Homeobox protein Meis2

1

14

High-throughput

0.479

High

243714

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

14

High-throughput

0.479

High

246897

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

259064

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.479

High

316961

MTA2
Metastasis-associated protein MTA2

1

13

High-throughput

0.479

High

321646

PRP6
Pre-mRNA-processing factor 6

1

1

High-throughput

0.479

High

333154

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.479

High

414481

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

457639

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

537768

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

600365

ZNF24
Zinc finger protein 24

1

3

High-throughput

0.479

High

600909

HSP76
Heat shock 70 kDa protein 6

1

2

High-throughput

0.479

High

674302

BRD2
Bromodomain-containing protein 2

1

9

High-throughput

0.479

High

681706

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.479

High

701212

PSB5
Proteasome subunit beta type-5

1

2

High-throughput

0.479

High

703368

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

14

High-throughput

0.479

High

718616

CDC27
Cell division cycle protein 27 homolog

1

2

High-throughput

0.479

High

729417

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

3

High-throughput

0.479

High

789206

NUP62
Nuclear pore glycoprotein p62

1

1

High-throughput

0.479

High

823861

PBX1
Pre-B-cell leukemia transcription factor 1

1

12

High-throughput

0.479

High

823911

PBX2
Pre-B-cell leukemia transcription factor 2

1

13

High-throughput

0.479

High

823976

PBX3
Pre-B-cell leukemia transcription factor 3

1

15

High-throughput

0.479

High

837805

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

838776

MTREX
Exosome RNA helicase MTR4

1

4

High-throughput

0.479

High

905470

HCFC1
Host cell factor 1

1

1

High-throughput

0.479

High

910650

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

High-throughput

0.479

High

911068

IMA1
Importin subunit alpha-1

1

2

High-throughput

0.479

High

913017

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

2

High-throughput

0.479

High

916027

NUP98
Nuclear pore complex protein Nup98-Nup96

1

2

High-throughput

0.479

High

920225

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.479

High

938180

PKNX1
Homeobox protein PKNOX1

1

13

High-throughput

0.479

High

940415

MAZ
Myc-associated zinc finger protein

1

2

High-throughput

0.479

High

974187

RUXG
Small nuclear ribonucleoprotein G

1

1

High-throughput

0.479

High

980200

H4
Histone H4

1

2

High-throughput

0.479

High

997476

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.479

High

1007770

RAE1L
mRNA export factor RAE1

1

5

High-throughput

0.479

High

1033176

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

1054777

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.479

High

1055264

MTG8
Protein CBFA2T1

1

1

High-throughput

0.479

High

1086809

BPTF
Nucleosome-remodeling factor subunit BPTF

1

18

High-throughput

0.479

High

1100288

TIF1B
Transcription intermediary factor 1-beta

1

6

High-throughput

0.479

High

1121647

MORC3
MORC family CW-type zinc finger protein 3

1

2

High-throughput

0.479

High

1123595

ZMYM3
Zinc finger MYM-type protein 3

1

5

High-throughput

0.479

High

1130407

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

4

High-throughput

0.479

High

1132921

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

7

High-throughput

0.479

High

1146782

PCBP1
Poly(rC)-binding protein 1

1

2

High-throughput

0.479

High

1146976

PCBP2
Poly(rC)-binding protein 2

1

2

High-throughput

0.479

High

1151287

MED1
Mediator of RNA polymerase II transcription subunit 1

1

8

High-throughput

0.479

High

1186300

MA7D1
MAP7 domain-containing protein 1

1

7

High-throughput

0.479

High

1217557

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

1

High-throughput

0.479

High

1219739

ZMYM4
Zinc finger MYM-type protein 4

1

5

High-throughput

0.479

High

1246152

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

3

High-throughput

0.479

High

1286785

KAISO
Transcriptional regulator Kaiso

1

4

High-throughput

0.479

High

1295294

P66A
Transcriptional repressor p66-alpha

1

3

High-throughput

0.479

High

1309947

MA7D3
MAP7 domain-containing protein 3

1

2

High-throughput

0.479

High

1311714

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

2

High-throughput

0.479

High

1312487

PHC2
Polyhomeotic-like protein 2

1

7

High-throughput

0.479

High

1340790

COP1
E3 ubiquitin-protein ligase COP1

1

5

High-throughput

0.479

High

1347533

SMRC2
SWI/SNF complex subunit SMARCC2

1

14

High-throughput

0.479

High

1360997

P66B
Transcriptional repressor p66-beta

1

3

High-throughput

0.479

High

1370508

GATA6
Transcription factor GATA-6

1

6

High-throughput

0.479

High

1389874

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

1399702

RBM14
RNA-binding protein 14

1

2

High-throughput

0.479

High

1400606

KI20B
Kinesin-like protein KIF20B

1

4

High-throughput

0.479

High

1403268

RBM15
RNA-binding protein 15

1

3

High-throughput

0.479

High

1404336

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.479

High

1404719

RING2
E3 ubiquitin-protein ligase RING2

1

13

High-throughput

0.479

High

1405554

ARI3A
AT-rich interactive domain-containing protein 3A

1

9

High-throughput

0.479

High

1405555

LIMD2
LIM domain-containing protein 2

1

3

High-throughput

0.479

High

1405558

CHM4A
Charged multivesicular body protein 4a

1

3

High-throughput

0.479

High

1405562

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

1405566

ING3
Inhibitor of growth protein 3

1

2

High-throughput

0.479

High

1405567

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

10

High-throughput

0.479

High

1405571

ZMYM2
Zinc finger MYM-type protein 2

1

5

High-throughput

0.479

High

1405572

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

1

12

High-throughput

0.479

High

1405573

APC7
Anaphase-promoting complex subunit 7

1

2

High-throughput

0.479

High

1405574

RCOR1
REST corepressor 1

1

17

High-throughput

0.479

High

1405576

TRI33
E3 ubiquitin-protein ligase TRIM33

1

7

High-throughput

0.479

High

1405578

SCML2
Sex comb on midleg-like protein 2

1

5

High-throughput

0.479

High

1405583

SALL2
Sal-like protein 2

1

4

High-throughput

0.479

High

1405584

MTF2
Metal-response element-binding transcription factor 2

1

2

High-throughput

0.479

High

128049

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.458

High

137472

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.458

High

211025

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.458

High

425005

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.458

High

485717

RU2A
U2 small nuclear ribonucleoprotein A'

1

0

High-throughput

0.458

High

608717

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

High-throughput

0.458

High

640995

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

High-throughput

0.458

High

654669

TCEA1
Transcription elongation factor A protein 1

1

0

High-throughput

0.458

High

770414

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.458

High

890574

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.458

High

900475

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.458

High

906158

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

912109

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

969031

PRS8
26S proteasome regulatory subunit 8

1

0

High-throughput

0.458

High

972755

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.458

High

973550

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.458

High

973802

RUXE
Small nuclear ribonucleoprotein E

1

0

High-throughput

0.458

High

1053382

CTSL2
CTD small phosphatase-like protein 2

1

0

High-throughput

0.458

High

1138544

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1153580

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.458

High

1292968

AROS
Active regulator of SIRT1

1

0

High-throughput

0.458

High

1307303

H2A2B
Histone H2A type 2-B

1

0

High-throughput

0.458

High

1336718

RCBT1
RCC1 and BTB domain-containing protein 1

1

0

High-throughput

0.458

High

1339148

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1348114

PUM2
Pumilio homolog 2

1

0

High-throughput

0.458

High

1400859

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1403006

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.458

High

1405276

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.458

High

1405557

REPI1
DNA-binding protein REPIN1

1

0

High-throughput

0.458

High

1405559

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.458

High

1405560

OSBL8
Oxysterol-binding protein-related protein 8

1

0

High-throughput

0.458

High

1405563

MSL2
E3 ubiquitin-protein ligase MSL2

1

0

High-throughput

0.458

High

1405564

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.458

High

1405565

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

0

High-throughput

0.458

High

1405570

SENP1
Sentrin-specific protease 1

1

0

High-throughput

0.458

High

1405579

RTRAF
RNA transcription, translation and transport factor protein

1

0

High-throughput

0.458

High

1405580

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

0

High-throughput

0.458

High

1405581

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.458

High

1405582

CHTOP
Chromatin target of PRMT1 protein

1

0

High-throughput

0.458

High

1405585

MB212
Protein mab-21-like 2

1

0

High-throughput

0.458

High

764986

CTNB1
Catenin beta-1

1

4

Small-scale

0.445

High

157772

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

680474

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

1094247

ACACA
Acetyl-CoA carboxylase 1

1

2

High-throughput

0.437

High

1214760

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

High-throughput

0.437

High

1215295

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

1

2

High-throughput

0.437

High

1391141

CHMP6
Charged multivesicular body protein 6

1

3

High-throughput

0.437

High

1405556

NUP58
Nucleoporin p58/p45

1

1

High-throughput

0.437

High

1405568

CHMP5
Charged multivesicular body protein 5

1

3

High-throughput

0.437

High

1405569

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.437

High

733988

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

0

High-throughput

0.249

Low

1327413

MPND
MPN domain-containing protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025