Protein: TBX3
T-box transcription factor TBX3 (T-box protein 3)

Gene: TBX3
Organism: Homo sapiens
Interactions: 63
UniProt ID: O15119

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

178507

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

1

High-throughput

0.628

High

178483

GSC
Homeobox protein goosecoid

1

20

High-throughput

0.618

High

178472

PML
Protein PML

2

6

Small-scale

0.584

High

178511

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.580

High

178457

TBX3
T-box transcription factor TBX3

1

12

Small-scale

0.575

High

178495

TLE5
TLE family member 5

1

20

High-throughput

0.573

High

178479

SOX2
Transcription factor SOX-2

1

14

High-throughput

0.536

High

178480

CDK8
Cyclin-dependent kinase 8

1

3

High-throughput

0.536

High

178510

CDCA5
Sororin

1

1

High-throughput

0.536

High

178514

DCP1A
mRNA-decapping enzyme 1A

1

4

High-throughput

0.536

High

178515

DJC11
DnaJ homolog subfamily C member 11

1

2

High-throughput

0.536

High

178471

MK03
Mitogen-activated protein kinase 3

1

0

High-throughput

0.513

High

178464

ANXA5
Annexin A5

1

0

High-throughput

0.493

High

178459

KI21B
Kinesin-like protein KIF21B

1

1

High-throughput

0.489

High

178504

KI21A
Kinesin-like protein KIF21A

1

1

High-throughput

0.489

High

178517

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.489

High

178465

CSF3
Granulocyte colony-stimulating factor

1

1

High-throughput

0.481

High

178505

ZNF34
Zinc finger protein 34

1

1

High-throughput

0.481

High

142717

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

178458

HDAC3
Histone deacetylase 3

1

7

Small-scale

0.479

High

178462

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

1

High-throughput

0.479

High

178463

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

178466

ANDR
Androgen receptor

1

7

High-throughput

0.479

High

178467

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

178468

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

178469

XRCC5
X-ray repair cross-complementing protein 5

1

4

High-throughput

0.479

High

178470

SP100
Nuclear autoantigen Sp-100

1

10

High-throughput

0.479

High

178475

CTNB1
Catenin beta-1

1

4

High-throughput

0.479

High

178476

RBMX
RNA-binding motif protein, X chromosome

1

1

High-throughput

0.479

High

178477

IF4A3
Eukaryotic initiation factor 4A-III

1

2

High-throughput

0.479

High

178478

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

178482

HDAC4
Histone deacetylase 4

1

8

High-throughput

0.479

High

178484

KLF3
Krueppel-like factor 3

1

12

High-throughput

0.479

High

178486

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

High-throughput

0.479

High

178487

H4
Histone H4

1

2

High-throughput

0.479

High

178488

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

1

High-throughput

0.479

High

178493

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

178494

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

178497

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

178498

PABP4
Polyadenylate-binding protein 4

1

1

High-throughput

0.479

High

178499

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.479

High

178500

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

High-throughput

0.479

High

178501

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

178508

HDAC2
Histone deacetylase 2

1

7

Small-scale

0.479

High

178509

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

Small-scale

0.479

High

178516

HDAC5
Histone deacetylase 5

1

8

Small-scale

0.479

High

178490

PR20D
Proline-rich protein 20D

1

3

High-throughput

0.470

High

178506

Q8N4W3
Granulocyte colony-stimulating factor

1

1

High-throughput

0.470

High

178460

SVIL
Supervillin

1

0

High-throughput

0.458

High

178461

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

178473

PDIA3
Protein disulfide-isomerase A3

1

0

High-throughput

0.458

High

178481

EMD
Emerin

1

0

High-throughput

0.458

High

178496

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.458

High

178503

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

178491

PR20A
Proline-rich protein 20A

1

3

High-throughput

0.439

High

178513

PKHF2
Pleckstrin homology domain-containing family F member 2

1

4

High-throughput

0.439

High

178492

S25A3
Solute carrier family 25 member 3

1

1

High-throughput

0.437

High

178502

UFSP1
Ufm1-specific protease 1

2

0

High-throughput

0.316

High

178474

CAH8
Carbonic anhydrase-related protein

1

0

High-throughput

0.299

High

178512

TOLIP
Toll-interacting protein

1

0

High-throughput

0.282

High

178489

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

0

Small-scale

0.261

Low

178485

MYL6
Myosin light polypeptide 6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025