HitPredict

Interactor 1: SOCS1 (O15524)
Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3)
Gene: SOCS1

Interactor 2: IRS2 (Q9Y4H2)
Insulin receptor substrate 2 (IRS-2)
Gene: IRS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	27507812, 29991678, 12228220
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 211 Hs			1 1338
+	Hs
		147455 SOCS3_HUMAN (39-207): 3.53e-40: 138: 27.73		IRS2_HUMAN (1-1338): 1.35e-161: 522: 100.00
+	Hs
		924983 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		IRS2_HUMAN (1-1338): 1.35e-161: 522: 100.00
+	Mm
		946348 GRB2_MOUSE (52-181): 5.95e-36: 127: 16.79		IRS2_MOUSE (1-1338): 2.79e-152: 496: 83.20
+	Rn
		94388 GRB2_RAT (52-181): 4.7e-36: 127: 16.79		F1MAL5_RAT (1-1338): 4.63e-149: 488: 82.77
+	Hs
		146670 SOCS7_HUMAN (22-209): 5.3e-49: 169: 22.75		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		181808 SOCS1_HUMAN (1-211): 6.15e-51: 165: 100.00		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		208999 NCK2_HUMAN (2-175): 8.86e-39: 139: 19.77		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		147396 SOCS3_HUMAN (39-207): 3.53e-40: 138: 27.73		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		412057 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		724527 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		146566 SOCS2_HUMAN (37-211): 5.65e-43: 144: 28.57		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		147457 SOCS6_HUMAN (66-209): 1.11e-39: 144: 26.06		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		151689 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Mm
		724599 GRB2_MOUSE (52-181): 5.95e-36: 127: 16.79		IRS1_MOUSE (21-1164): 5.96e-79: 287: 32.74
+	Rn
		724631 GRB2_RAT (52-181): 4.7e-36: 127: 16.79		IRS1_RAT (21-1197): 4.35e-79: 287: 32.63
+	Hs
		151763 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		411582 LCK_HUMAN (4-194): 3.94e-39: 142: 13.46		MUC1_HUMAN (289-926): 1.69e-34: 146: 14.46
+	Hs
		554292 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		MUC1_HUMAN (289-926): 1.69e-34: 146: 14.46
+	Hs
		924760 GRB2_HUMAN (52-181): 4.7e-36: 127: 16.79		PRG4_HUMAN (753-1310): 1.28e-17: 91.5: 10.79
+	Hs
		412362 FYN_HUMAN (64-194): 1.54e-37: 138: 18.44		MAGE1_HUMAN (729-1177): 8.9e-12: 72.1: 15.30