Protein: SMAD5
Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)

Gene: SMAD5
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q99717

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001649 - osteoblast differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1106680

SMAD4
Mothers against decapentaplegic homolog 4

3

18

Small-scale

0.837

High

1406696

SMUF1
E3 ubiquitin-protein ligase SMURF1

10

20

Small-scale

0.754

High

1406694

SMUF2
E3 ubiquitin-protein ligase SMURF2

5

20

Small-scale

0.719

High

1014595

SMAD3
Mothers against decapentaplegic homolog 3

1

19

Small-scale

0.665

High

1153889

SMAD2
Mothers against decapentaplegic homolog 2

1

19

Small-scale

0.665

High

1153999

SMAD1
Mothers against decapentaplegic homolog 1

1

20

High-throughput

0.656

High

219876

SMAD6
Mothers against decapentaplegic homolog 6

1

20

Small-scale

0.618

High

555419

SKI
Ski oncogene

1

16

Small-scale

0.618

High

1406685

SMAD5
Mothers against decapentaplegic homolog 5

1

19

High-throughput

0.618

High

1007978

PO6F2
POU domain, class 6, transcription factor 2

2

3

High-throughput

0.606

High

1406693

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.602

High

1406689

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

2

20

Small-scale

0.600

High

1067641

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.586

High

1048385

ACVR1
Activin receptor type-1

2

20

Small-scale

0.584

High

1119489

RUNX2
Runt-related transcription factor 2

2

16

Small-scale

0.584

High

1381232

WBP2
WW domain-binding protein 2

2

0

High-throughput

0.580

High

1293287

LSR
Lipolysis-stimulated lipoprotein receptor

2

2

High-throughput

0.574

High

169727

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

9

Small-scale

0.552

High

1370323

CSN5
COP9 signalosome complex subunit 5

1

5

Small-scale

0.552

High

1199145

PKHO1
Pleckstrin homology domain-containing family O member 1

1

0

Small-scale

0.537

High

608339

EGLN
Endoglin

1

1

High-throughput

0.536

High

608719

DDX5
Probable ATP-dependent RNA helicase DDX5

1

10

Small-scale

0.536

High

1314534

TM192
Transmembrane protein 192

1

2

High-throughput

0.536

High

1384114

ARRD3
Arrestin domain-containing protein 3

1

1

High-throughput

0.536

High

1406697

RNC
Ribonuclease 3

1

3

Small-scale

0.536

High

1369682

KLK6
Kallikrein-6

1

1

High-throughput

0.515

High

1406686

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

1

High-throughput

0.515

High

231006

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.513

High

1086478

KCNH2
Voltage-gated inwardly rectifying potassium channel KCNH2

1

0

High-throughput

0.513

High

1406690

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

128051

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

4

High-throughput

0.508

High

286044

SF3B1
Splicing factor 3B subunit 1

1

5

High-throughput

0.508

High

473010

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.508

High

478178

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.508

High

647635

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

2

High-throughput

0.508

High

655316

SFPQ
Splicing factor, proline- and glutamine-rich

1

5

High-throughput

0.508

High

685701

U2AF2
Splicing factor U2AF 65 kDa subunit

1

4

High-throughput

0.508

High

776117

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.508

High

861742

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

High-throughput

0.508

High

1050819

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

2

High-throughput

0.508

High

1148017

SF3B3
Splicing factor 3B subunit 3

1

1

High-throughput

0.508

High

1273202

CXXC5
CXXC-type zinc finger protein 5

1

3

High-throughput

0.508

High

1315836

AN13A
Ankyrin repeat domain-containing protein 13A

1

3

High-throughput

0.508

High

1367837

RYR2
Ryanodine receptor 2

1

6

High-throughput

0.508

High

1406687

SOX7
Transcription factor SOX-7

1

14

High-throughput

0.508

High

1406688

RBM4
RNA-binding protein 4

1

2

High-throughput

0.508

High

1406699

MTMRA
Myotubularin-related protein 10

1

4

High-throughput

0.508

High

1406704

CHMP3
Charged multivesicular body protein 3

1

3

High-throughput

0.508

High

1106294

ROCK1
Rho-associated protein kinase 1

1

5

Small-scale

0.501

High

1022459

IDD
Integral membrane protein DGCR2/IDD

1

4

High-throughput

0.489

High

1406703

MAN1
Inner nuclear membrane protein Man1

1

14

High-throughput

0.489

High

931206

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.486

High

999620

HBG2
Hemoglobin subunit gamma-2

1

0

High-throughput

0.486

High

1356396

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.486

High

1403531

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

High-throughput

0.486

High

129365

MEN1
Menin

1

5

Small-scale

0.479

High

173269

XPO1
Exportin-1

1

10

High-throughput

0.479

High

216525

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

6

Small-scale

0.479

High

282412

MED24
Mediator of RNA polymerase II transcription subunit 24

1

5

Small-scale

0.479

High

685325

PAX6
Paired box protein Pax-6

1

4

Small-scale

0.479

High

696319

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

862406

YAP1
Transcriptional coactivator YAP1

1

20

Small-scale

0.479

High

881591

CDK8
Cyclin-dependent kinase 8

1

10

Small-scale

0.479

High

897470

TOB1
Protein Tob1

1

12

Small-scale

0.479

High

915478

HMGA2
High mobility group protein HMGI-C

1

3

Small-scale

0.479

High

1029921

RUNX1
Runt-related transcription factor 1

1

16

Small-scale

0.479

High

1110030

HDAC1
Histone deacetylase 1

1

12

Small-scale

0.479

High

1115024

CUL4A
Cullin-4A

1

7

High-throughput

0.479

High

1117067

RUNX3
Runt-related transcription factor 3

1

16

Small-scale

0.479

High

1153311

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.479

High

1255226

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1369154

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.479

High

1406691

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1406692

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

6

Small-scale

0.479

High

1406698

MED29
Mediator of RNA polymerase II transcription subunit 29

1

1

Small-scale

0.479

High

1406700

HECW2
E3 ubiquitin-protein ligase HECW2

1

20

High-throughput

0.479

High

1406701

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1406702

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

Small-scale

0.479

High

766790

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

1157604

TAF12
Transcription initiation factor TFIID subunit 12

1

0

Small-scale

0.458

High

1162773

GLO2
Hydroxyacylglutathione hydrolase, mitochondrial

1

0

High-throughput

0.458

High

1406695

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.458

High

1359308

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.328

High

1388167

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.279

Low

1399596

OPALI
Opalin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025