HitPredict

Interactor 1: RAB6 (O18334)
Ras-related protein Rab6 (Protein warthog)
Gene: RAB6

Interactor 2: Q9VXE3 (Q9VXE3)
Rho-associated protein kinase (EC 2.7.11.1)
Gene: Rok

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15710747
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras, Ras~Rho_Binding
Common GO terms	GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 208 Dm			1 1390
+	Dm
		185664 RAB6_DROME (1-208): 7.45e-88: 258: 100.00		X2JE40_DROME (1-1365): 0: 791: 99.85
+	Dm
		1358762 RAB5_DROME (12-206): 1.51e-49: 162: 41.03		X2JE40_DROME (1-1365): 0: 791: 99.85
+	Hs
		254466 RB11A_HUMAN (1-207): 1.84e-87: 258: 30.84		ROCK2_HUMAN (1-1377): 0: 651: 42.20
+	Hs
		592236 RAB5A_HUMAN (7-174): 1.11e-48: 159: 44.64		ROCK1_HUMAN (19-1371): 0: 697: 42.34
+	Hs
		148636 RAB1A_HUMAN (1-207): 1.65e-92: 270: 36.23		CTRO_HUMAN (29-1305): 7.62e-139: 472: 20.82
+	Hs
		149274 RAB1B_HUMAN (7-207): 7.23e-90: 263: 35.82		CTRO_HUMAN (29-1305): 7.62e-139: 472: 20.82
+	Dm
		116371 RAB6_DROME (1-208): 7.45e-88: 258: 100.00		M9PI41_DROME (5-1305): 1.92e-129: 443: 17.97
+	At
		221736 RAA1E_ARATH (1-207): 6.36e-86: 254: 32.56		KIN10_ARATH (86-483): 5.11e-123: 394: 18.63
+	Hs
		148389 RAB5A_HUMAN (7-174): 1.11e-48: 159: 44.64		CTRO_HUMAN (29-1305): 7.62e-139: 472: 20.82
+	Hs
		914081 RB11A_HUMAN (1-207): 1.84e-87: 258: 30.84		STK38_HUMAN (75-402): 5.95e-76: 262: 40.22
+	Hs
		914124 RB11A_HUMAN (1-207): 1.84e-87: 258: 30.84		MRCKA_HUMAN (674-1315): 3.84e-46: 184: 12.71
+	Hs
		592267 RAB5A_HUMAN (7-174): 1.11e-48: 159: 44.64		STK38_HUMAN (75-402): 5.95e-76: 262: 40.22
+	Dm
		1358706 RAB5_DROME (12-206): 1.51e-49: 162: 41.03		WARTS_DROME (17-386): 1.92e-63: 238: 35.02