HitPredict

Interactor 1: TMPS2 (O15393)
Transmembrane protease serine 2 (EC 3.4.21.122) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain]
Gene: TMPRSS2

Interactor 2: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34709727, 38272320
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 492 Hs			1 654
+	Hs
		535494 TMPSD_HUMAN (5-488): 1.19e-112: 346: 31.35		BIP_HUMAN (19-654): 0: 913: 100.00
+	Hs
		537900 TMPS5_HUMAN (73-491): 8.85e-97: 301: 33.57		HSP7C_HUMAN (26-637): 0: 914: 66.02
+	Hs
		535541 TMPS5_HUMAN (73-491): 8.85e-97: 301: 33.57		BIP_HUMAN (19-654): 0: 913: 100.00
+	Hs
		535733 TEST_HUMAN (244-492): 3.44e-98: 300: 37.55		BIP_HUMAN (19-654): 0: 913: 100.00
+	Hs
		534619 TRYB2_HUMAN (256-485): 9.68e-97: 294: 36.36		BIP_HUMAN (19-654): 0: 913: 100.00
+	Hs
		931108 TMPS5_HUMAN (73-491): 8.85e-97: 301: 33.57		HSP72_HUMAN (25-636): 0: 903: 64.51
+	Hs
		457944 TRY1_HUMAN (248-491): 1.47e-90: 278: 34.96		BIP_HUMAN (19-654): 0: 913: 100.00
+	Hs
		458001 TRY2_HUMAN (255-491): 2.74e-89: 275: 35.98		BIP_HUMAN (19-654): 0: 913: 100.00