Protein: TRY1
Serine protease 1 (EC 3.4.21.4) (Anionic trypsin I) (Anionic trypsin-I) (Beta-trypsin) (Cationic trypsinogen) (Pretrypsinogen I) (Trypsin I) (Trypsin-1) [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2]

Gene: TRY1, PRSS1
Organism: Homo sapiens
Interactions: 69
UniProt ID: P07477

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006508 - proteolysis
GO:0007586 - digestion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

457942

TRY2
Trypsin-2

1

9

High-throughput

0.691

High

457943

A2AP
Alpha-2-antiplasmin

1

20

Small-scale

0.647

High

457955

SPB8
Serpin B8

1

20

Small-scale

0.647

High

136779

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

9

High-throughput

0.618

High

457951

SYUA
Alpha-synuclein

2

3

Small-scale

0.584

High

457959

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.553

High

457986

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

5

High-throughput

0.553

High

194497

KDM6A
Lysine-specific demethylase 6A

1

4

High-throughput

0.536

High

389929

ALBU
Albumin

1

7

High-throughput

0.536

High

240514

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.533

High

457962

UBE3A
Ubiquitin-protein ligase E3A

1

4

Small-scale

0.501

High

457950

EPHA3
Ephrin type-A receptor 3

1

11

High-throughput

0.500

High

253476

ANM3
Protein arginine N-methyltransferase 3

1

1

High-throughput

0.489

High

457944

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.489

High

457967

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.489

High

457977

FANCM
Fanconi anemia group M protein

1

5

High-throughput

0.489

High

457979

AGRV1
Adhesion G-protein coupled receptor V1

1

12

High-throughput

0.489

High

457997

ST38L
Serine/threonine-protein kinase 38-like

1

1

High-throughput

0.489

High

457999

CDY2
Testis-specific chromodomain protein Y 2

1

1

High-throughput

0.489

High

137919

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

407827

SEMG1
Semenogelin-1

1

2

High-throughput

0.479

High

457945

PPAP
Prostatic acid phosphatase

1

2

High-throughput

0.479

High

457975

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

457989

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

457952

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

457988

RNF26
E3 ubiquitin-protein ligase RNF26

1

3

Small-scale

0.457

High

457949

GATA2
Endothelial transcription factor GATA-2

1

1

High-throughput

0.457

High

457946

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.445

High

290837

PPM1B
Protein phosphatase 1B

1

1

High-throughput

0.437

High

348941

LATS1
Serine/threonine-protein kinase LATS1

1

1

High-throughput

0.437

High

370948

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

405689

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.437

High

457948

EPHA1
Ephrin type-A receptor 1

1

9

High-throughput

0.437

High

457953

TISD
mRNA decay activator protein ZFP36L2

1

2

High-throughput

0.437

High

457954

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

457956

EFNA3
Ephrin-A3

1

2

High-throughput

0.437

High

457958

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

457961

K1C17
Keratin, type I cytoskeletal 17

1

4

High-throughput

0.437

High

457964

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.437

High

457966

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.437

High

457968

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

3

High-throughput

0.437

High

457971

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

457972

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.437

High

457973

ZFY16
Zinc finger FYVE domain-containing protein 16

1

2

Small-scale

0.437

High

457976

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.437

High

457978

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.437

High

457980

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.437

High

457982

THOC3
THO complex subunit 3

1

1

Small-scale

0.437

High

457985

CP250
Centrosome-associated protein CEP250

1

3

High-throughput

0.437

High

457987

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.437

High

457990

ASXL3
Putative Polycomb group protein ASXL3

1

3

High-throughput

0.437

High

457991

DDX24
ATP-dependent RNA helicase DDX24

1

2

High-throughput

0.437

High

457994

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

457995

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

3

High-throughput

0.437

High

457996

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

457998

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.437

High

457960

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.407

High

457963

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.279

Low

457974

PIWL4
Piwi-like protein 4

1

0

High-throughput

0.279

Low

457983

EPAS1
Endothelial PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

457984

CND3
Condensin complex subunit 3

1

0

High-throughput

0.279

Low

457993

PRDM5
PR domain zinc finger protein 5

1

0

High-throughput

0.279

Low

457947

BTF3
Transcription factor BTF3

1

0

High-throughput

0.249

Low

457957

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

457965

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.249

Low

457969

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

457970

CDC73
Parafibromin

1

0

High-throughput

0.249

Low

457992

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

457981

THOC1
THO complex subunit 1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025