HitPredict

Interactor 1: KLOT (O35082)
Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide]
Gene: Kl

Interactor 2: FGFR4 (Q03142)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (Protein-tyrosine kinase receptor MPK-11) (CD antigen CD334)
Gene: FGFR4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	16436388, 19966287
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Glyco_hydro_1~I-set
Common GO terms	GO:0008543 - fibroblast growth factor receptor signaling pathway GO:0017134 - fibroblast growth factor binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1014 Mm			1 799
+	Mm
		192164 KLOT_MOUSE (34-1014): 0: 1385: 100.00		FGFR3_MOUSE (3-782): 0: 722: 58.81
+	Mm
		192157 KLOT_MOUSE (34-1014): 0: 1385: 100.00		FGFR1_MOUSE (1-791): 0: 709: 54.33
+	Mm
		93854 KLOT_MOUSE (34-1014): 0: 1385: 100.00		E9QNJ9_MOUSE (3-782): 0: 709: 56.91
+	Mm
		192159 KLOT_MOUSE (34-1014): 0: 1385: 100.00		FGFR2_MOUSE (3-794): 0: 707: 55.10
+	Hs
		608033 KLOTB_HUMAN (15-1013): 0: 1183: 45.48		FGFR4_HUMAN (13-799): 0: 736: 90.60
+	Hs
		601541 KLOTB_HUMAN (15-1013): 0: 1183: 45.48		FGFR2_HUMAN (3-794): 0: 734: 55.10
+	Mm
		975159 KLOTB_MOUSE (15-1014): 0: 1146: 44.81		FGFR4_MOUSE (1-799): 0: 755: 100.00
+	Hs
		609401 KLOTB_HUMAN (15-1013): 0: 1183: 45.48		FGFR3_HUMAN (3-798): 0: 714: 59.20
+	Hs
		508088 KLOTB_HUMAN (15-1013): 0: 1183: 45.48		FGFR1_HUMAN (1-791): 0: 711: 54.33
+	Mm
		555271 KLOTB_MOUSE (15-1014): 0: 1146: 44.81		FGFR1_MOUSE (1-791): 0: 709: 54.33
+	Ce
		1014307 Q18758_CAEEL (521-951): 1.56e-143: 439: 25.73		EGL15_CAEEL (11-242): 1.01e-24: 112: 16.17