HitPredict - High confidence protein-protein interactions

Interactor 1: INSI1 (O15503)
Insulin-induced gene 1 protein (INSIG-1)
Gene: INSIG1

Interactor 2: INSI1 (O15503)
Insulin-induced gene 1 protein (INSIG-1)
Gene: INSIG1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19617589
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0006641 - triglyceride metabolic process GO:0006695 - cholesterol biosynthetic process GO:0008142 - oxysterol binding and 16 others more... GO:0032869 - cellular response to insulin stimulus GO:0032933 - SREBP signaling pathway GO:0032937 - SREBP-SCAP-Insig complex GO:0036315 - cellular response to sterol GO:0036316 - SREBP-SCAP complex retention in endoplasmic reticulum GO:0042472 - inner ear morphogenesis GO:0042474 - middle ear morphogenesis GO:0042632 - cholesterol homeostasis GO:0045541 - negative regulation of cholesterol biosynthetic process GO:0045599 - negative regulation of fat cell differentiation GO:0045717 - negative regulation of fatty acid biosynthetic process GO:0060021 - roof of mouth development GO:0060363 - cranial suture morphogenesis GO:0070862 - negative regulation of protein exit from endoplasmic reticulum GO:0140311 - protein sequestering activity GO:1901303 - negative regulation of cargo loading into COPII-coated vesicle
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	277
Hs

1	277

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Last updated: 11Aug2025