HitPredict

Interactor 1: RING1 (O35730)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Transcription repressor Ring1A)
Gene: RING1

Interactor 2: RYBP (Q8CCI5)
RING1 and YY1-binding protein (Death effector domain-associated factor) (DED-associated factor)
Gene: RYBP

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.874

Property	Details
Experiments	17070805, 22325148, 10369680
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, two hybrid, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0006338 - chromatin remodeling GO:0031519 - PcG protein complex GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Mm			1 228
+	Hs
		987991 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12
+	Hs
		987989 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33
+	Mm
		1208123 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00
+	Hs
		1233162 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12
+	Mm
		1307837 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		YAF2_MOUSE (3-227): 4.01e-57: 181: 54.67
+	Hs
		1222214 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33
+	Hs
		718410 PCGF2_HUMAN (31-378): 9.27e-64: 209: 16.67		RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12
+	Mm
		620789 PCGF2_MOUSE (31-378): 1.03e-59: 199: 16.94		RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00
+	Hs
		718409 PCGF2_HUMAN (31-378): 9.27e-64: 209: 16.67		YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33
+	Dm
		1361718 RING1_DROME (1-403): 1.54e-71: 232: 35.46		Q9W215_DROME (3-197): 8.13e-42: 141: 37.95
+	Hs
		718013 BMI1_HUMAN (31-370): 4.27e-51: 176: 15.07		RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12
+	Hs
		585013 RO52_HUMAN (33-307): 1.34e-43: 159: 13.46		RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12
+	Hs
		718000 BMI1_HUMAN (31-370): 4.27e-51: 176: 15.07		YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33
+	Hs
		1108517 PCGF3_HUMAN (34-273): 3.39e-39: 142: 16.33		RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12
+	Mm
		1208119 PCGF1_MOUSE (25-130): 1.16e-38: 141: 24.77		RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00
+	Hs
		1233178 PCGF1_HUMAN (25-130): 8.93e-39: 141: 24.77		RYBP_HUMAN (1-228): 1.09e-59: 189: 99.12
+	Mm
		1208122 PCGF6_MOUSE (31-157): 1.53e-36: 138: 23.08		RYBP_MOUSE (1-228): 4.83e-60: 190: 100.00
+	Hs
		1108516 PCGF3_HUMAN (34-273): 3.39e-39: 142: 16.33		YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33
+	Hs
		1222217 PCGF1_HUMAN (25-130): 8.93e-39: 141: 24.77		YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33
+	Hs
		1197569 PCGF5_HUMAN (31-147): 5.49e-37: 137: 23.33		YAF2_HUMAN (3-227): 1.42e-52: 169: 53.33