Protein: FXYD6
FXYD domain-containing ion transport regulator 6 (Phosphohippolin)

Gene: FXYD6
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q9H0Q3

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006813 - potassium ion transport
GO:0006814 - sodium ion transport
GO:0017080 - sodium channel regulator activity
GO:0042734 - presynaptic membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

565703

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

2

High-throughput

0.691

High

931293

AT12A
Potassium-transporting ATPase alpha chain 2

1

2

High-throughput

0.691

High

1197884

S39AC
Zinc transporter ZIP12

2

2

High-throughput

0.628

High

1384347

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

3

3

High-throughput

0.616

High

194747

FFAR2
Free fatty acid receptor 2

2

3

High-throughput

0.606

High

253168

MOT2
Monocarboxylate transporter 2

2

2

High-throughput

0.606

High

337906

CLD7
Claudin-7

2

1

High-throughput

0.606

High

1134162

NTCP
Hepatic sodium/bile acid cotransporter

2

3

High-throughput

0.606

High

1186040

SOAT
Sodium-dependent organic anion transporter

2

3

High-throughput

0.606

High

1256791

LHPL2
LHFPL tetraspan subfamily member 2 protein

2

1

High-throughput

0.606

High

1307733

CLC10
C-type lectin domain family 10 member A

2

1

High-throughput

0.606

High

1347198

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

1

High-throughput

0.606

High

1384644

APH1A
Gamma-secretase subunit APH-1A

2

1

High-throughput

0.606

High

1411142

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

1

High-throughput

0.606

High

1430274

S39A2
Zinc transporter ZIP2

2

2

High-throughput

0.606

High

1350061

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.602

High

1430287

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

3

2

High-throughput

0.597

High

181427

PGRC2
Membrane-associated progesterone receptor component 2

2

0

High-throughput

0.580

High

292500

RHBL1
Rhomboid-related protein 1

2

0

High-throughput

0.580

High

407130

HG2A
HLA class II histocompatibility antigen gamma chain

2

0

High-throughput

0.580

High

669067

FPR2
N-formyl peptide receptor 2

2

0

High-throughput

0.580

High

870078

KCNJ6
G protein-activated inward rectifier potassium channel 2

2

0

High-throughput

0.580

High

870785

CXA8
Gap junction alpha-8 protein

2

0

High-throughput

0.580

High

1242812

RNK
Ribonuclease kappa

2

0

High-throughput

0.580

High

1326899

EMC5
ER membrane protein complex subunit 5

2

0

High-throughput

0.580

High

1335833

APCDL
Protein APCDD1-like

2

0

High-throughput

0.580

High

1390785

S47A1
Multidrug and toxin extrusion protein 1

2

0

High-throughput

0.580

High

1400544

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

1430283

RHCG
Ammonium transporter Rh type C

2

0

High-throughput

0.580

High

167000

MGST3
Glutathione S-transferase 3, mitochondrial

2

1

High-throughput

0.553

High

1109041

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

1142937

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

1

High-throughput

0.553

High

1280812

S35E3
Solute carrier family 35 member E3

2

1

High-throughput

0.553

High

1326979

SVOP
Synaptic vesicle 2-related protein

2

2

High-throughput

0.553

High

1328808

TM86B
Lysoplasmalogenase TMEM86B

2

1

High-throughput

0.553

High

1428505

ELOV4
Very long chain fatty acid elongase 4

2

1

High-throughput

0.553

High

1430275

S35C2
Solute carrier family 35 member C2

2

3

High-throughput

0.553

High

1430280

ELOV2
Very long chain fatty acid elongase 2

2

1

High-throughput

0.553

High

1207968

COL12
Collectin-12

1

1

High-throughput

0.536

High

1349688

CIP2A
Protein CIP2A

1

1

High-throughput

0.536

High

1430286

DYN3
Dynamin-3

1

1

High-throughput

0.536

High

399513

C4BPA
C4b-binding protein alpha chain

1

0

High-throughput

0.518

High

193448

GPR42
G-protein coupled receptor 42

1

3

High-throughput

0.515

High

443964

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

0

High-throughput

0.513

High

1005534

GPC5
Glypican-5 [Cleaved into: Secreted glypican-5]

1

0

High-throughput

0.513

High

1092389

TSN31
Tetraspanin-31

1

0

High-throughput

0.513

High

164638

TNPO2
Transportin-2

1

2

High-throughput

0.489

High

1109506

ATR
Serine/threonine-protein kinase ATR

1

1

High-throughput

0.489

High

1245223

BRAT1
Integrator complex assembly factor BRAT1

1

1

High-throughput

0.489

High

1371189

GLMN
Glomulin

1

1

High-throughput

0.489

High

1430285

XPO7
Exportin-7

1

4

High-throughput

0.489

High

138576

CLD5
Claudin-5

1

1

High-throughput

0.481

High

258669

G37L1
G-protein coupled receptor 37-like 1

1

1

High-throughput

0.481

High

303359

BEST1
Bestrophin-1

1

1

High-throughput

0.481

High

1274088

MOT13
Monocarboxylate transporter 13

1

3

High-throughput

0.481

High

1292372

UN93A
Protein unc-93 homolog A

1

1

High-throughput

0.481

High

1351700

GP152
Probable G-protein coupled receptor 152

1

2

High-throughput

0.481

High

1359068

APH1B
Gamma-secretase subunit APH-1B

1

1

High-throughput

0.481

High

1430281

SCN3B
Sodium channel regulatory subunit beta-3

1

1

High-throughput

0.481

High

1430282

GPC5D
G-protein coupled receptor family C group 5 member D

1

1

High-throughput

0.481

High

230427

CREB3
Cyclic AMP-responsive element-binding protein 3

1

3

High-throughput

0.464

High

337137

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.460

High

718731

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

High-throughput

0.460

High

719838

V2R
Vasopressin V2 receptor

1

0

High-throughput

0.460

High

762185

TRFR
Thyrotropin-releasing hormone receptor

1

0

High-throughput

0.460

High

786841

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

Small-scale

0.460

High

1400776

MYCT
Proton myo-inositol cotransporter

1

0

High-throughput

0.460

High

1420278

S19A3
Thiamine transporter 2

1

0

High-throughput

0.460

High

1430284

LAT2
Large neutral amino acids transporter small subunit 2

1

0

High-throughput

0.460

High

530359

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

386214

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.439

High

1207613

F209A
Protein FAM209A

1

1

High-throughput

0.439

High

1430272

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.439

High

49753

TMM72
Transmembrane protein 72

2

0

High-throughput

0.316

High

142110

PEX12
Peroxisome assembly protein 12

2

0

High-throughput

0.316

High

1187558

AR13B
ADP-ribosylation factor-like protein 13B

2

0

High-throughput

0.316

High

1198906

NACHO
Novel acetylcholine receptor chaperone

2

0

High-throughput

0.316

High

1243402

TM154
Transmembrane protein 154

2

0

High-throughput

0.316

High

1254308

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

0

High-throughput

0.316

High

1328198

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.316

High

1359036

TM239
Transmembrane protein 239

2

0

High-throughput

0.316

High

1385806

T4S18
Transmembrane 4 L6 family member 18

2

0

High-throughput

0.316

High

1398473

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.316

High

1428303

DERL2
Derlin-2

2

0

High-throughput

0.316

High

1429126

MFF
Mitochondrial fission factor

2

0

High-throughput

0.316

High

1430273

CERS4
Ceramide synthase 4

2

0

High-throughput

0.316

High

1430279

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.316

High

248417

GDF9
Growth/differentiation factor 9

1

0

High-throughput

0.282

High

414592

P53
Cellular tumor antigen p53

1

0

High-throughput

0.282

High

572207

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.282

High

942871

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.282

High

1047862

TLE1
Transducin-like enhancer protein 1

1

0

High-throughput

0.282

High

1105173

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.282

High

1209161

RBM48
RNA-binding protein 48

1

0

High-throughput

0.282

High

1395660

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.282

High

1428804

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.282

High

1430278

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.282

High

1360349

ATRIP
ATR-interacting protein

1

0

High-throughput

0.279

Low

1389585

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

331485

APOL3
Apolipoprotein L3

1

0

High-throughput

0.251

Low

1092091

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

0

High-throughput

0.251

Low

1207767

TMM31
Transmembrane protein 31

1

0

High-throughput

0.251

Low

1248358

TM205
Transmembrane protein 205

1

0

High-throughput

0.251

Low

1393567

TM41A
Transmembrane protein 41A

1

0

High-throughput

0.251

Low

1395624

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.251

Low

1396399

F210B
Protein FAM210B, mitochondrial

1

0

High-throughput

0.251

Low

1430276

KISHB
Protein kish-B

1

0

High-throughput

0.251

Low

1430277

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.251

Low

1430288

TMX2
Thioredoxin-related transmembrane protein 2

1

0

High-throughput

0.251

Low

1430289

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.251

Low

106626

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1256653

Q6ZUH1
cDNA FLJ43719 fis, clone TESOP2006060

1

0

High-throughput

0.238

Low

1394027

Q96I30
GPR108 protein

1

0

High-throughput

0.238

Low

1216653

PRAM5
PRAME family member 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025