Protein: FXYD3
FXYD domain-containing ion transport regulator 3 (Chloride conductance inducer protein Mat-8) (Mammary tumor 8 kDa protein) (Phospholemman-like) (Sodium/potassium-transporting ATPase subunit FXYD3)

Gene: FXYD3
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q14802

Gene Ontology (top 5):
GO:0005254 - chloride channel activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006813 - potassium ion transport
GO:0006814 - sodium ion transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1132571

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

3

3

High-throughput

0.661

High

194697

FFAR2
Free fatty acid receptor 2

2

3

High-throughput

0.606

High

213684

AQP9
Aquaporin-9

2

2

High-throughput

0.606

High

258640

G37L1
G-protein coupled receptor 37-like 1

2

1

High-throughput

0.606

High

934207

BI1
Bax inhibitor 1

2

1

High-throughput

0.606

High

1007435

S35B1
Solute carrier family 35 member B1

2

1

High-throughput

0.606

High

1132538

NTCP
Hepatic sodium/bile acid cotransporter

2

3

High-throughput

0.606

High

1132539

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

1

High-throughput

0.606

High

1132543

SOAT
Sodium-dependent organic anion transporter

2

3

High-throughput

0.606

High

1132548

F209A
Protein FAM209A

2

1

High-throughput

0.606

High

1132555

MOT12
Monocarboxylate transporter 12

2

2

High-throughput

0.606

High

1132559

TM86A
Lysoplasmalogenase TMEM86A

2

1

High-throughput

0.606

High

1132562

BEST2
Bestrophin-2a

2

1

High-throughput

0.606

High

1132566

GP152
Probable G-protein coupled receptor 152

2

2

High-throughput

0.606

High

1132572

TLCD1
TLC domain-containing protein 1

2

1

High-throughput

0.606

High

1132576

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

1

High-throughput

0.606

High

1132580

GHITM
Growth hormone-inducible transmembrane protein

2

1

High-throughput

0.606

High

1132582

S39A2
Zinc transporter ZIP2

2

2

High-throughput

0.606

High

1132587

SCN3B
Sodium channel regulatory subunit beta-3

2

1

High-throughput

0.606

High

1132588

GPC5D
G-protein coupled receptor family C group 5 member D

2

1

High-throughput

0.606

High

1132596

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

2

High-throughput

0.606

High

230320

CREB3
Cyclic AMP-responsive element-binding protein 3

2

3

High-throughput

0.590

High

194826

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

2

0

High-throughput

0.580

High

337732

SGPL1
Sphingosine-1-phosphate lyase 1

2

0

High-throughput

0.580

High

359986

NB5R3
NADH-cytochrome b5 reductase 3

2

0

High-throughput

0.580

High

528755

MGST1
Microsomal glutathione S-transferase 1

2

0

High-throughput

0.580

High

549774

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.580

High

553401

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

2

0

High-throughput

0.580

High

592935

ANK1
Ankyrin-1

2

0

High-throughput

0.580

High

762127

CNR2
Cannabinoid receptor 2

2

0

High-throughput

0.580

High

845025

EAA3
Excitatory amino acid transporter 3

2

0

High-throughput

0.580

High

926768

VMAT1
Chromaffin granule amine transporter

2

0

High-throughput

0.580

High

941745

TM50B
Transmembrane protein 50B

2

0

High-throughput

0.580

High

1007393

S35A1
CMP-sialic acid transporter

2

0

High-throughput

0.580

High

1100661

STX3
Syntaxin-3

2

0

High-throughput

0.580

High

1132541

LTC4S
Leukotriene C4 synthase

2

0

High-throughput

0.580

High

1132545

TM52B
Transmembrane protein 52B

2

0

High-throughput

0.580

High

1132546

SGMR2
Sigma intracellular receptor 2

2

0

High-throughput

0.580

High

1132549

TSPO2
Translocator protein 2

2

0

High-throughput

0.580

High

1132551

MFSD5
Molybdate-anion transporter

2

0

High-throughput

0.580

High

1132556

T179B
Transmembrane protein 179B

2

0

High-throughput

0.580

High

1132558

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

2

0

High-throughput

0.580

High

1132592

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.580

High

231797

MFS11
UNC93-like protein MFSD11

2

1

High-throughput

0.553

High

1108896

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

1132579

IF3M
Translation initiation factor IF-3, mitochondrial

2

1

High-throughput

0.553

High

1132584

S35C2
Solute carrier family 35 member C2

2

3

High-throughput

0.553

High

1132564

CIP2A
Protein CIP2A

1

1

High-throughput

0.536

High

1132568

NDRG1
Protein NDRG1

1

5

High-throughput

0.536

High

1132569

TNPO1
Transportin-1

1

2

High-throughput

0.536

High

1132589

NDRG3
Protein NDRG3

1

5

High-throughput

0.536

High

1132593

NDRG4
Protein NDRG4

1

5

High-throughput

0.536

High

1132595

DYN3
Dynamin-3

1

1

High-throughput

0.536

High

193411

GPR42
G-protein coupled receptor 42

1

3

High-throughput

0.515

High

1132542

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.513

High

1132544

TKFC
Triokinase/FMN cyclase

1

0

High-throughput

0.513

High

1132574

EXOC2
Exocyst complex component 2

1

0

High-throughput

0.513

High

1132575

XPO6
Exportin-6

1

0

High-throughput

0.513

High

1132590

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.513

High

652516

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

1

High-throughput

0.494

High

164575

TNPO2
Transportin-2

1

2

High-throughput

0.489

High

665097

COT2
COUP transcription factor 2

1

1

High-throughput

0.489

High

1109446

ATR
Serine/threonine-protein kinase ATR

1

1

High-throughput

0.489

High

1132552

BRAT1
Integrator complex assembly factor BRAT1

1

1

High-throughput

0.489

High

1132567

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.489

High

1132570

GLMN
Glomulin

1

1

High-throughput

0.489

High

1132581

XPO5
Exportin-5

1

4

High-throughput

0.489

High

1132591

XPO7
Exportin-7

1

4

High-throughput

0.489

High

1132598

TNPO3
Transportin-3

1

4

High-throughput

0.489

High

1132599

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

1

High-throughput

0.489

High

1132561

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.481

High

1132547

XKR3
XK-related protein 3

1

0

High-throughput

0.460

High

385746

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.439

High

1132550

Q5VU21
PAI-1 mRNA-binding protein variant

1

1

High-throughput

0.417

High

168089

TIM23
Mitochondrial import inner membrane translocase subunit Tim23

2

0

High-throughput

0.316

High

641311

SIAL
Integrin-binding sialoprotein

2

0

High-throughput

0.316

High

1132554

SPNS3
Protein spinster homolog 3

2

0

High-throughput

0.316

High

1132560

KASH5
Protein KASH5

2

0

High-throughput

0.316

High

1132565

AGR3
Anterior gradient protein 3

2

0

High-throughput

0.316

High

1132573

TMM80
Transmembrane protein 80

2

0

High-throughput

0.316

High

1132578

B2L13
Bcl-2-like protein 13

2

0

High-throughput

0.316

High

1132583

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.316

High

1132586

FXL12
F-box/LRR-repeat protein 12

1

0

High-throughput

0.282

High

1132553

THADA
tRNA

1

0

High-throughput

0.279

Low

1132557

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.279

Low

1132563

TBC15
TBC1 domain family member 15

1

0

High-throughput

0.279

Low

1132577

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.279

Low

1132585

GEMI8
Gem-associated protein 8

1

0

High-throughput

0.279

Low

1132594

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

0

High-throughput

0.279

Low

1132597

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.279

Low

516261

DWORF
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF

1

0

High-throughput

0.268

Low

352706

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.265

Low

1132540

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025