HitPredict

Interactor 1: RING1 (O35730)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Transcription repressor Ring1A)
Gene: RING1

Interactor 2: CBX7 (Q8VDS3)
Chromobox protein homolog 7
Gene: CBX7

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22325148
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0003682 - chromatin binding GO:0006325 - chromatin organization GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Mm			1 158
+	Mm
		1257537 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX7_MOUSE (1-158): 8.04e-53: 166: 100.00
+	Mm
		193417 RING1_MOUSE (1-406): 8.02e-116: 345: 100.00		CBX8_MOUSE (1-123): 3.89e-30: 113: 44.93
+	Hs
		123243 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX4_HUMAN (1-126): 3e-32: 121: 46.03
+	Hs
		316019 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX6_HUMAN (1-125): 2.05e-30: 115: 39.86
+	Mm
		193405 RING1_MOUSE (1-406): 8.02e-116: 345: 100.00		CBX2_MOUSE (2-100): 2.6e-26: 104: 41.41
+	Hs
		988024 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX8_HUMAN (1-81): 2.86e-29: 111: 64.20
+	Hs
		987972 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX2_HUMAN (2-100): 8.27e-26: 103: 41.41
+	Mm
		1164651 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		Q6TKP2_MOUSE (1-125): 4.91e-37: 135: 39.86
+	Hs
		987963 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX3_HUMAN (9-154): 2.17e-23: 92.2: 22.45
+	Hs
		949760 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX1_HUMAN (17-154): 3.94e-23: 91.5: 21.48
+	Mm
		1321737 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX6_MOUSE (1-125): 1.48e-33: 123: 39.86
+	Mm
		223231 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX4_MOUSE (1-126): 2.02e-32: 122: 46.83
+	Hs
		123308 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		CBX4_HUMAN (1-126): 3e-32: 121: 46.03
+	Hs
		316133 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		CBX6_HUMAN (1-125): 2.05e-30: 115: 39.86
+	Mm
		1321744 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX8_MOUSE (1-123): 3.89e-30: 113: 44.93
+	Mm
		675501 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX2_MOUSE (2-100): 2.6e-26: 104: 41.41
+	Hs
		327842 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		CBX7_HUMAN (48-158): 1.39e-12: 64.9: 57.52
+	Mm
		1321739 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		Q9DCC5_MOUSE (9-154): 2.17e-23: 92.2: 22.45
+	Mm
		613033 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		CBX3_MOUSE (9-154): 2.75e-23: 91.9: 21.77
+	Hs
		327858 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		CBX7_HUMAN (48-158): 1.39e-12: 64.9: 57.52