HitPredict

Interactor 1: RING1 (O35730)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Transcription repressor Ring1A)
Gene: RING1

Interactor 2: EED (Q921E6)
Polycomb protein EED
Gene: EED

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001739 - sex chromatin GO:0003682 - chromatin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Mm			1 441
+	Hs
		268040 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Mm
		1265453 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Hs
		268241 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Hs
		267918 PCGF2_HUMAN (31-378): 9.27e-64: 209: 16.67		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Mm
		1206589 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		TBL1R_MOUSE (4-335): 1.66e-56: 196: 11.40
+	Hs
		1304089 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40
+	Mm
		620792 PCGF2_MOUSE (31-378): 1.03e-59: 199: 16.94		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Hs
		267917 BMI1_HUMAN (31-370): 4.27e-51: 176: 15.07		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Mm
		639477 BMI1_MOUSE (31-370): 1.41e-49: 172: 14.87		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Mm
		1246746 PCGF1_MOUSE (25-130): 1.16e-38: 141: 24.77		EED_MOUSE (1-441): 2.11e-92: 287: 100.00
+	Hs
		268253 PCGF1_HUMAN (25-130): 8.93e-39: 141: 24.77		EED_HUMAN (1-441): 2.11e-92: 287: 100.00
+	Hs
		1281338 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32
+	Hs
		903159 RING1_HUMAN (1-406): 1.05e-111: 335: 96.55		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09
+	Hs
		903455 RING2_HUMAN (8-406): 3.35e-98: 298: 54.25		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09
+	Mm
		903677 RING2_MOUSE (8-406): 2.19e-98: 298: 54.25		WDR5_MOUSE (335-440): 3.22e-14: 75.3: 15.09
+	Hs
		585027 RO52_HUMAN (33-307): 1.34e-43: 159: 13.46		FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32
+	Hs
		903462 BARD1_HUMAN (4-352): 2.59e-50: 183: 15.55		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09
+	Hs
		717626 BMI1_HUMAN (31-370): 4.27e-51: 176: 15.07		WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09
+	Hs
		196962 BMI1_HUMAN (31-370): 4.27e-51: 176: 15.07		PRP4_HUMAN (337-437): 3.12e-09: 60.7: 16.51
+	Hs
		585092 RO52_HUMAN (33-307): 1.34e-43: 159: 13.46		FBW1B_HUMAN (160-352): 1.57e-12: 71.3: 18.97