HitPredict

Interactor 1: PK3CD (O35904)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
Gene: Pik3cd

Interactor 2: RASK (P32883)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: Kras

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23706742
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras, PI3K_rbd~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0010628 - positive regulation of gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1043 Mm			1 189
+	Mm
		193571 PK3CD_MOUSE (1-1043): 0: 1306: 100.00		RASH_MOUSE (1-188): 3.11e-87: 256: 86.77
+	Mm
		193564 PK3CD_MOUSE (1-1043): 0: 1306: 100.00		RASN_MOUSE (1-189): 5.14e-87: 255: 86.77
+	Hs
		126186 PK3CD_HUMAN (1-1043): 0: 1293: 94.35		RASH_HUMAN (1-188): 3.11e-87: 256: 86.77
+	Mm
		193570 PK3CD_MOUSE (1-1043): 0: 1306: 100.00		RRAS2_MOUSE (3-188): 1.47e-54: 173: 54.12
+	Mm
		1142560 PK3CB_MOUSE (1-1042): 0: 1137: 55.39		RASH_MOUSE (1-188): 3.11e-87: 256: 86.77
+	Hs
		349947 PK3CB_HUMAN (1-1042): 0: 1110: 55.30		RASK_HUMAN (1-189): 6.74e-78: 232: 98.94
+	Mm
		787349 PK3CA_MOUSE (1-1040): 0: 1052: 39.24		RASH_MOUSE (1-188): 3.11e-87: 256: 86.77
+	Mm
		440301 PK3CA_MOUSE (1-1040): 0: 1052: 39.24		RASN_MOUSE (1-189): 5.14e-87: 255: 86.77
+	Hs
		349170 PK3CA_HUMAN (1-1040): 0: 1048: 39.05		RASH_HUMAN (1-188): 3.11e-87: 256: 86.77
+	Hs
		348554 PK3CA_HUMAN (1-1040): 0: 1048: 39.05		RASN_HUMAN (1-189): 3.17e-86: 253: 86.24
+	Mm
		699616 PK3CA_MOUSE (1-1040): 0: 1052: 39.24		RASK_MOUSE (1-189): 2.66e-78: 233: 100.00
+	Hs
		349946 PK3CA_HUMAN (1-1040): 0: 1048: 39.05		RASK_HUMAN (1-189): 6.74e-78: 232: 98.94
+	Hs
		787242 PK3CA_HUMAN (1-1040): 0: 1048: 39.05		RB11B_HUMAN (4-176): 5.49e-73: 221: 34.29
+	Dm
		442990 P91634_DROME (9-1043): 0: 1004: 38.38		RAS1_DROME (1-165): 2.98e-88: 258: 86.06
+	Mm
		787346 PK3CA_MOUSE (1-1040): 0: 1052: 39.24		RRAS2_MOUSE (3-188): 1.47e-54: 173: 54.12
+	Hs
		349183 PK3CG_HUMAN (16-1037): 0: 953: 30.66		RASH_HUMAN (1-188): 3.11e-87: 256: 86.77
+	Hs
		348567 PK3CG_HUMAN (16-1037): 0: 953: 30.66		RASN_HUMAN (1-189): 3.17e-86: 253: 86.24
+	Mm
		440303 PK3CG_MOUSE (1-1037): 0: 949: 30.30		RASN_MOUSE (1-189): 5.14e-87: 255: 86.77
+	Hs
		349970 PK3CG_HUMAN (16-1037): 0: 953: 30.66		RASK_HUMAN (1-189): 6.74e-78: 232: 98.94
+	Dm
		381632 P91634_DROME (9-1043): 0: 1004: 38.38		RAS2_DROME (1-189): 3.37e-55: 174: 54.92