HitPredict

Interactor 1: M3K7 (O43318)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: MAP3K7

Interactor 2: EZRI (P15311)
Ezrin (Cytovillin) (Villin-2) (p81)
Gene: EZR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	29568061, 32707033
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 606 Hs			1 586
+	Hs
		201243 M3K7_HUMAN (1-606): 0: 574: 100.00		RADI_HUMAN (1-586): 7.83e-165: 484: 76.28
+	Hs
		201222 M3K7_HUMAN (1-606): 0: 574: 100.00		MOES_HUMAN (1-586): 4.45e-161: 474: 72.70
+	Hs
		547018 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00
+	Hs
		546943 EPHA2_HUMAN (16-358): 2.84e-101: 331: 26.67		EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00
+	Hs
		719456 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		MERL_HUMAN (2-586): 3.18e-146: 436: 44.37
+	Hs
		983673 FAK1_HUMAN (30-603): 3.48e-121: 385: 21.04		E41L5_HUMAN (5-586): 7.7e-142: 430: 21.28
+	Hs
		719689 EPHA5_HUMAN (16-325): 4.76e-100: 328: 28.27		RADI_HUMAN (1-586): 7.83e-165: 484: 76.28
+	Hs
		665158 EPHA2_HUMAN (16-358): 2.84e-101: 331: 26.67		MERL_HUMAN (2-586): 3.18e-146: 436: 44.37
+	Hs
		665337 EPHA2_HUMAN (16-358): 2.84e-101: 331: 26.67		E41LA_HUMAN (1-576): 5.03e-116: 361: 16.47
+	Hs
		719505 M3K11_HUMAN (29-287): 5.32e-37: 149: 35.27		MERL_HUMAN (2-586): 3.18e-146: 436: 44.37