HitPredict

Interactor 1: LAT (O43561)
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)
Gene: LAT

Interactor 2: GRAP2 (O75791)
GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona)
Gene: GRAP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	10021361, 10224278
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 330
+	Hs
		207410 LAT_HUMAN (1-262): 1.6e-153: 429: 100.00		LCK_HUMAN (3-136): 1.04e-53: 185: 34.46
+	Hs
		207423 LAT_HUMAN (1-262): 1.6e-153: 429: 100.00		PLCG1_HUMAN (24-328): 1.98e-33: 132: 16.08
+	Hs
		207411 LAT_HUMAN (1-262): 1.6e-153: 429: 100.00		FYN_HUMAN (222-329): 3.95e-22: 98.7: 30.00
+	Hs
		207440 LAT_HUMAN (1-262): 1.6e-153: 429: 100.00		GRB2_HUMAN (274-326): 2.04e-13: 70.3: 38.89
+	Hs
		207446 LAT_HUMAN (1-262): 1.6e-153: 429: 100.00		GRAP_HUMAN (279-329): 6e-12: 66.1: 32.69
+	Hs
		207421 LAT_HUMAN (1-262): 1.6e-153: 429: 100.00		PLCG2_HUMAN (47-244): 5.79e-09: 59.5: 16.58
+	Mm
		222780 LAT_MOUSE (24-262): 7.33e-91: 270: 59.44		PLCG1_MOUSE (24-328): 1.03e-33: 133: 15.79
+	Mm
		222756 LAT_MOUSE (24-262): 7.33e-91: 270: 59.44		FYN_MOUSE (222-329): 3.84e-22: 98.7: 30.00
+	Mm
		222775 LAT_MOUSE (24-262): 7.33e-91: 270: 59.44		GRB2_MOUSE (274-326): 2.5e-13: 69.9: 38.89
+	Mm
		222800 LAT_MOUSE (24-262): 7.33e-91: 270: 59.44		GRAP_MOUSE (3-53): 7.63e-10: 59.9: 26.92