HitPredict

Interactor 1: LAT (O43561)
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)
Gene: LAT

Interactor 2: GRAP (Q13588)
GRB2-related adapter protein
Gene: GRAP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	9489702, 12186560
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction GO:0008180 - COP9 signalosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 217
+	Hs
		207440 LAT_HUMAN (1-262): 1.6e-153: 429: 100.00		GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72
+	Hs
		207410 LAT_HUMAN (1-262): 1.6e-153: 429: 100.00		LCK_HUMAN (4-204): 1.02e-41: 149: 26.98
+	Hs
		207420 LAT_HUMAN (1-262): 1.6e-153: 429: 100.00		VAV_HUMAN (2-60): 1.27e-16: 80: 33.90
+	Hs
		207411 LAT_HUMAN (1-262): 1.6e-153: 429: 100.00		FYN_HUMAN (154-215): 1.46e-12: 67.7: 31.25
+	Hs
		207401 LAT_HUMAN (1-262): 1.6e-153: 429: 100.00		GRAP2_HUMAN (3-55): 1.64e-11: 64.4: 33.96
+	Mm
		222775 LAT_MOUSE (24-262): 7.33e-91: 270: 59.44		GRB2_MOUSE (1-216): 3.23e-69: 212: 59.72
+	Mm
		222800 LAT_MOUSE (24-262): 7.33e-91: 270: 59.44		GRAP_MOUSE (1-217): 1.59e-64: 200: 92.17
+	Mm
		222753 LAT_MOUSE (24-262): 7.33e-91: 270: 59.44		VAV_MOUSE (2-60): 1.5e-16: 79.6: 33.90
+	Mm
		222756 LAT_MOUSE (24-262): 7.33e-91: 270: 59.44		FYN_MOUSE (154-215): 1.46e-12: 67.7: 31.25