HitPredict

Interactor 1: PPIP1 (O43586)
Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)
Gene: PSTPIP1

Interactor 2: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	19041431, 16418535
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0001931 - uropod GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis and 1 others more... GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 416 Hs			1 870
+	Hs
		840812 PACN1_HUMAN (14-416): 1.18e-60: 204: 20.70		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Mm
		760475 PACN1_MOUSE (14-416): 1.65e-59: 201: 20.00		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Mm
		760485 PACN3_MOUSE (13-416): 1.94e-58: 198: 20.38		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Mm
		760487 PACN2_MOUSE (13-416): 2.67e-56: 194: 17.97		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Hs
		840860 PACN3_HUMAN (13-416): 3.2e-56: 192: 21.23		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		840864 PACN2_HUMAN (13-416): 1.94e-53: 186: 17.76		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		840723 FBP1L_HUMAN (12-383): 4.6e-46: 169: 15.93		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		840700 CIP4_HUMAN (12-357): 1.11e-40: 154: 16.76		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		840798 FNBP1_HUMAN (12-383): 7.41e-39: 149: 14.87		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		983406 PACN1_HUMAN (14-416): 1.18e-60: 204: 20.70		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Mm
		760451 PACN1_MOUSE (14-416): 1.65e-59: 201: 20.00		DYN1_MOUSE (1-844): 0: 1003: 79.23
+	Rn
		599414 PACN1_RAT (14-416): 1.11e-59: 202: 20.00		DYN1_RAT (1-846): 0: 994: 78.57
+	Hs
		983416 PACN3_HUMAN (13-416): 3.2e-56: 192: 21.23		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Mm
		1142989 PACN1_MOUSE (14-416): 1.65e-59: 201: 20.00		DYN3_MOUSE (1-870): 0: 992: 77.90
+	Rn
		996551 PACN1_RAT (14-416): 1.11e-59: 202: 20.00		DYN3_RAT (1-870): 0: 991: 77.65
+	Hs
		983417 PACN2_HUMAN (13-416): 1.94e-53: 186: 17.76		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		983392 NOSTN_HUMAN (22-394): 8.19e-45: 164: 15.92		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Dm
		649307 Q9VDI1_DROME (13-414): 3.08e-55: 191: 18.16		DYN_DROME (6-842): 0: 928: 66.23
+	Ce
		760501 Q6AHQ8_CAEEL (13-414): 1.11e-46: 169: 14.47		DYN1_CAEEL (3-823): 0: 899: 61.86
+	Ce
		760496 Q09989_CAEEL (13-414): 5.7e-46: 167: 14.47		DYN1_CAEEL (3-823): 0: 899: 61.86