HitPredict

Interactor 1: PPIP1 (O43586)
Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)
Gene: PSTPIP1

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.735

Property	Details
Experiments	9422760, 32296183, unassigned1304, 35152348, 11971877, 14707117
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 416 Hs			1 780
+	Mm
		728826 PPIP1_MOUSE (1-416): 2.25e-81: 258: 87.98		PTN12_MOUSE (1-780): 0: 560: 83.10
+	Hs
		983514 PPIP2_HUMAN (2-330): 6.72e-57: 191: 43.64		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Mm
		728830 PPIP2_MOUSE (2-330): 2.56e-57: 192: 43.33		PTN12_MOUSE (1-780): 0: 560: 83.10
+	Mm
		665999 PPIP1_MOUSE (1-416): 2.25e-81: 258: 87.98		PTN22_MOUSE (1-779): 1.51e-143: 443: 32.93
+	Hs
		207851 PPIP1_HUMAN (1-416): 3.14e-83: 262: 100.00		PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01
+	Mm
		956955 PPIP1_MOUSE (1-416): 2.25e-81: 258: 87.98		PTN18_MOUSE (2-446): 8.05e-136: 411: 32.97
+	Hs
		207769 PPIP1_HUMAN (1-416): 3.14e-83: 262: 100.00		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		207829 PPIP1_HUMAN (1-416): 3.14e-83: 262: 100.00		PTN18_HUMAN (14-446): 4.35e-123: 378: 32.66
+	Mm
		666001 PPIP2_MOUSE (2-330): 2.56e-57: 192: 43.33		PTN22_MOUSE (1-779): 1.51e-143: 443: 32.93
+	Hs
		1333999 PPIP2_HUMAN (2-330): 6.72e-57: 191: 43.64		PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01
+	Mm
		1142213 PPIP2_MOUSE (2-330): 2.56e-57: 192: 43.33		PTN18_MOUSE (2-446): 8.05e-136: 411: 32.97
+	Hs
		1307332 PPIP2_HUMAN (2-330): 6.72e-57: 191: 43.64		PTN18_HUMAN (14-446): 4.35e-123: 378: 32.66
+	Hs
		1078935 ITSN1_HUMAN (319-415): 5.56e-09: 60.5: 20.62		PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01
+	Mm
		719322 ITSN1_MOUSE (340-415): 3.53e-09: 61.2: 25.00		PTN11_MOUSE (7-351): 2.04e-124: 387: 31.48
+	Hs
		617105 FCHO2_HUMAN (2-385): 3.04e-54: 194: 18.50		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50