HitPredict - High confidence protein-protein interactions

Interactor 1: CHM2A (O43633)
Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1)
Gene: CHMP2A

Interactor 2: CHMP3 (Q9Y3E7)
Charged multivesicular body protein 3 (Chromatin-modifying protein 3) (Neuroendocrine differentiation factor) (Vacuolar protein sorting-associated protein 24) (hVps24)
Gene: CHMP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.904

Property	Details
Experiments	17159328, 16730941, 19525971, 23051622
Identification Methods	affinity chromatography technology, two hybrid, pull down, transmission electron microscopy, surface plasmon resonance, enzymatic footprinting
Interaction Type	physical association, direct interaction, protein cleavage

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0000421 - autophagosome membrane GO:0000776 - kinetochore GO:0000815 - ESCRT III complex GO:0001778 - plasma membrane repair GO:0005643 - nuclear pore and 33 others more... GO:0005765 - lysosomal membrane GO:0005771 - multivesicular body GO:0005828 - kinetochore microtubule GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006914 - autophagy GO:0006997 - nucleus organization GO:0007080 - mitotic metaphase chromosome alignment GO:0010824 - regulation of centrosome duplication GO:0015031 - protein transport GO:0016236 - macroautophagy GO:0019076 - viral release from host cell GO:0030496 - midbody GO:0031210 - phosphatidylcholine binding GO:0031468 - nuclear membrane reassembly GO:0032509 - endosome transport via multivesicular body sorting pathway GO:0032585 - multivesicular body membrane GO:0036258 - multivesicular body assembly GO:0039702 - viral budding via host ESCRT complex GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0045324 - late endosome to vacuole transport GO:0046761 - viral budding from plasma membrane GO:0051258 - protein polymerization GO:0051469 - vesicle fusion with vacuole GO:0061763 - multivesicular body-lysosome fusion GO:0061952 - midbody abscission GO:0070062 - extracellular exosome GO:0071985 - multivesicular body sorting pathway GO:0090148 - membrane fission GO:0097352 - autophagosome maturation GO:1901673 - regulation of mitotic spindle assembly GO:1902774 - late endosome to lysosome transport GO:1904930 - amphisome membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	222
Hs

1	222

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Last updated: 15 Jul 2024