HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: ILK (Q13418)
Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK)
Gene: ILK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10022929
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, Ank_2~SH3_1, PK_Tyr_Ser-Thr~SH3_1, Ank_2~SH3_9, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 452
+	Hs
		411626 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		LCK_HUMAN (167-449): 1.86e-109: 334: 21.99
+	Hs
		411607 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		LCK_HUMAN (167-449): 1.86e-109: 334: 21.99
+	Mm
		411918 P85A_MOUSE (166-379): 4.24e-24: 106: 16.36		LCK_MOUSE (167-449): 1.31e-109: 334: 21.99
+	Hs
		411545 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		LCK_HUMAN (167-449): 1.86e-109: 334: 21.99
+	Hs
		129163 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		LCK_HUMAN (167-449): 1.86e-109: 334: 21.99
+	Hs
		411559 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		LCK_HUMAN (167-449): 1.86e-109: 334: 21.99
+	Hs
		522833 CSK_HUMAN (191-378): 3.44e-32: 127: 24.87		SRC_HUMAN (173-448): 1.71e-98: 307: 24.56
+	Hs
		411648 BLK_HUMAN (7-204): 3.35e-19: 91: 19.80		LCK_HUMAN (167-449): 1.86e-109: 334: 21.99
+	Hs
		411544 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		LCK_HUMAN (167-449): 1.86e-109: 334: 21.99
+	Hs
		522796 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		SRC_HUMAN (173-448): 1.71e-98: 307: 24.56
+	Hs
		433263 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		YES_HUMAN (176-448): 5.77e-98: 305: 26.60
+	Hs
		454794 FGR_HUMAN (7-155): 1.02e-23: 104: 18.54		SRC_HUMAN (173-448): 1.71e-98: 307: 24.56
+	Hs
		411969 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		SRC_HUMAN (173-448): 1.71e-98: 307: 24.56
+	Hs
		129185 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		SRC_HUMAN (173-448): 1.71e-98: 307: 24.56
+	Hs
		433222 FGR_HUMAN (7-155): 1.02e-23: 104: 18.54		YES_HUMAN (176-448): 5.77e-98: 305: 26.60
+	Hs
		442772 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		SRC_HUMAN (173-448): 1.71e-98: 307: 24.56
+	Hs
		411946 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		YES_HUMAN (176-448): 5.77e-98: 305: 26.60
+	Mm
		403406 SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33		SRC_MOUSE (173-448): 1.69e-97: 304: 24.21
+	Hs
		411552 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		YES_HUMAN (176-448): 5.77e-98: 305: 26.60
+	Hs
		1078918 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		M3K20_HUMAN (188-451): 5.67e-26: 113: 27.99