HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: VASP (P50552)
Vasodilator-stimulated phosphoprotein (VASP)
Gene: VASP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0030838 - positive regulation of actin filament polymerization
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 380
+	Hs
		209112 NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00		MINK1_HUMAN (88-364): 7.5e-36: 141: 15.90
+	Hs
		557740 NCK1_HUMAN (1-379): 7.09e-91: 279: 68.24		MINK1_HUMAN (88-364): 7.5e-36: 141: 15.90
+	Ce
		110220 Q95PW9_CAEEL (1-379): 5.2e-75: 239: 37.88		H2L0C7_CAEEL (14-252): 5.05e-46: 161: 20.15
+	Hs
		412242 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		SPRE1_HUMAN (2-343): 2.84e-90: 280: 15.66
+	Hs
		129314 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		SPRE1_HUMAN (2-343): 2.84e-90: 280: 15.66
+	Hs
		840452 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		VASP_HUMAN (1-380): 1.43e-91: 281: 100.00
+	Hs
		442892 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		EVL_HUMAN (1-375): 2.06e-60: 202: 43.68
+	Hs
		523190 SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55		EVL_HUMAN (1-375): 2.06e-60: 202: 43.68
+	Hs
		412411 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		DYN3_HUMAN (15-212): 2.77e-38: 148: 20.98
+	Dm
		993191 GRAP_DROME (204-368): 9.19e-17: 80.1: 30.72		ENA_DROME (2-235): 1.21e-41: 158: 36.33
+	Mm
		1141147 GRB2_MOUSE (1-61): 1.04e-18: 85.9: 27.42		DYN3_MOUSE (15-212): 1.14e-38: 149: 20.49
+	Hs
		924956 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		DYN3_HUMAN (15-212): 2.77e-38: 148: 20.98
+	Hs
		411790 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		MINK1_HUMAN (88-364): 7.5e-36: 141: 15.90
+	Hs
		924703 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		MINK1_HUMAN (88-364): 7.5e-36: 141: 15.90
+	Mm
		763387 FYN_MOUSE (7-137): 2.1e-23: 103: 20.30		ENAH_MOUSE (109-379): 3.12e-16: 82.4: 28.17
+	Mm
		403433 SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33		ENAH_MOUSE (109-379): 3.12e-16: 82.4: 28.17