HitPredict

Interactor 1: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	25416956, 26871637
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Hs			1 669
+	Hs
		655455 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		411838 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		924829 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		655278 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		SMCA4_HUMAN (18-526): 1.58e-30: 130: 13.06
+	Hs
		1078919 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88
+	Hs
		655386 P85A_HUMAN (166-379): 4.05e-24: 106: 16.36		ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88
+	Hs
		1078828 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88
+	Hs
		61846 HCK_HUMAN (2-145): 5.1e-23: 102: 24.83		CC88B_HUMAN (60-668): 4.55e-16: 84.7: 12.48
+	Hs
		1349279 ITSN2_HUMAN (3-309): 6.32e-28: 117: 18.31		EP15R_HUMAN (483-668): 6.69e-11: 67.8: 12.90
+	Hs
		61738 A6H8W8_HUMAN (3-309): 8.49e-28: 117: 18.31		EP15R_HUMAN (483-668): 6.69e-11: 67.8: 12.90
+	Hs
		412287 FYN_HUMAN (7-137): 2.1e-23: 103: 20.30		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		129221 P85B_HUMAN (21-380): 7.78e-23: 102: 13.10		MYH10_HUMAN (321-640): 8.77e-09: 61.2: 18.79
+	Hs
		1078923 ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23		EP15R_HUMAN (483-668): 6.69e-11: 67.8: 12.90
+	Hs
		924566 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41
+	Hs
		411908 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		MRCKB_HUMAN (197-560): 2.09e-10: 66.2: 13.44
+	Hs
		924736 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		728465 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		MYH11_HUMAN (141-564): 3.93e-11: 68.9: 11.53
+	Hs
		411758 LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53		MRCKA_HUMAN (328-609): 6.79e-09: 61.6: 11.68
+	Hs
		924586 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77
+	Hs
		725134 GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81		MYH10_HUMAN (321-640): 8.77e-09: 61.2: 18.79