HitPredict

Interactor 1: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Interactor 2: CDC27 (P30260)
Cell division cycle protein 27 homolog (Anaphase-promoting complex subunit 3) (APC3) (CDC27 homolog) (CDC27Hs) (H-NUC)
Gene: CDC27

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.747

Property	Details
Experiments	28514442, 33961781, 27114510, 32152539, 32076268, 36520528, 22193957, 21926987
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 328 Hs			1 824
+	Hs
		672800 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		CDC27_HUMAN (1-824): 0: 625: 100.00
+	Hs
		211273 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		CDC23_HUMAN (371-823): 1.24e-24: 111: 12.64
+	Hs
		211167 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		CDC16_HUMAN (391-803): 1.46e-13: 76.5: 10.20
+	Ca
		483035 TUP1_CANAL (1-206): 8.77e-55: 188: 17.18		Q5ADP3_CANAL (285-709): 9.88e-38: 154: 12.42
+	Hs
		903589 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		APC7_HUMAN (290-823): 9.27e-61: 217: 16.28
+	Sp
		224207 TUP11_SCHPO (1-213): 6.22e-64: 214: 17.90		CYC8_SCHPO (21-470): 4.34e-11: 68.8: 11.11
+	Mm
		1246853 FBXW7_MOUSE (1-202): 1.89e-47: 171: 20.85		CDC16_MOUSE (437-803): 6.82e-14: 77.7: 11.14
+	Hs
		174768 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		OGT1_HUMAN (77-583): 5.18e-24: 110: 9.25
+	Sp
		224208 TUP12_SCHPO (170-318): 3.04e-26: 110: 17.45		CYC8_SCHPO (21-470): 4.34e-11: 68.8: 11.11