Protein: LAT1
Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)

Gene: LAT1, SLC7A5
Organism: Homo sapiens
Interactions: 221
UniProt ID: Q01650

Gene Ontology (top 5):
GO:0002720 - positive regulation of cytokine production involved in immune response
GO:0003333 - amino acid transmembrane transport
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

467459

4F2
Amino acid transporter heavy chain SLC3A2

6

11

Small-scale

0.946

High

820622

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.618

High

845607

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.618

High

1004032

CXAR
Coxsackievirus and adenovirus receptor

1

5

High-throughput

0.618

High

218069

TGON2
Trans-Golgi network integral membrane protein 2

2

2

High-throughput

0.584

High

374534

RASH
GTPase HRas

2

16

High-throughput

0.584

High

375420

RASK
GTPase KRas

2

20

High-throughput

0.584

High

540406

LAMP1
Lysosome-associated membrane glycoprotein 1

2

8

High-throughput

0.584

High

976211

RB11A
Ras-related protein Rab-11A

2

1

High-throughput

0.584

High

977943

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

1031341

IFM3
Interferon-induced transmembrane protein 3

2

2

High-throughput

0.584

High

1031828

YLAT2
Y+L amino acid transporter 2

1

16

High-throughput

0.575

High

1031859

LAT1L
Putative L-type amino acid transporter 1-like protein IMAA

1

12

High-throughput

0.575

High

1031886

YLAT1
Y+L amino acid transporter 1

1

16

High-throughput

0.575

High

395932

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

835647

KPCI
Protein kinase C iota type

2

1

High-throughput

0.571

High

905739

CAV2
Caveolin-2

2

3

High-throughput

0.571

High

1031776

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

3

High-throughput

0.571

High

1031782

PAK1
Serine/threonine-protein kinase PAK 1

2

2

High-throughput

0.571

High

1031856

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.559

High

1031783

MK07
Mitogen-activated protein kinase 7

2

0

High-throughput

0.547

High

363145

EGFR
Epidermal growth factor receptor

1

11

High-throughput

0.536

High

420497

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

3

High-throughput

0.536

High

905542

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.536

High

931344

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

3

High-throughput

0.536

High

1031800

TM63B
Mechanosensitive cation channel TMEM63B

1

1

High-throughput

0.536

High

1031811

MBOA1
Membrane-bound glycerophospholipid O-acyltransferase 1

1

1

High-throughput

0.536

High

1031819

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

1

High-throughput

0.536

High

1031829

NICA
Nicastrin

1

1

High-throughput

0.536

High

1031861

S38A1
Sodium-coupled neutral amino acid symporter 1

1

5

High-throughput

0.536

High

188863

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.515

High

774294

BASI
Basigin

1

8

High-throughput

0.515

High

1031815

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.515

High

1031830

NDRG1
Protein NDRG1

1

0

High-throughput

0.513

High

1031841

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.513

High

1031855

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

451368

NFM
Neurofilament medium polypeptide

1

2

High-throughput

0.489

High

1031850

TBA1C
Tubulin alpha-1C chain

1

2

High-throughput

0.489

High

125409

LEG9
Galectin-9

1

8

High-throughput

0.479

High

126553

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

130072

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.479

High

157254

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

178248

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

179874

BET1
BET1 homolog

1

3

High-throughput

0.479

High

189518

STX7
Syntaxin-7

1

9

High-throughput

0.479

High

225995

STX6
Syntaxin-6

1

3

High-throughput

0.479

High

247297

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.479

High

299152

FLOT1
Flotillin-1

1

2

High-throughput

0.479

High

315476

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

327227

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.479

High

341028

DIRA3
GTP-binding protein Di-Ras3

1

4

High-throughput

0.479

High

373887

RASN
GTPase NRas

1

20

High-throughput

0.479

High

413648

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

417384

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

High-throughput

0.479

High

418072

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

3

High-throughput

0.479

High

463460

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.479

High

466208

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

488773

FURIN
Furin

1

3

High-throughput

0.479

High

536993

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

560366

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

561999

LAMP2
Lysosome-associated membrane glycoprotein 2

1

8

High-throughput

0.479

High

580996

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

582750

EZRI
Ezrin

1

1

High-throughput

0.479

High

601244

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

603934

CXA1
Gap junction alpha-1 protein

1

4

High-throughput

0.479

High

630498

RAB3B
Ras-related protein Rab-3B

1

3

High-throughput

0.479

High

630769

RAB4A
Ras-related protein Rab-4A

1

10

High-throughput

0.479

High

631171

RAB5A
Ras-related protein Rab-5A

1

7

High-throughput

0.479

High

692931

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

710181

EPHA2
Ephrin type-A receptor 2

1

11

High-throughput

0.479

High

715545

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

766183

NOS2
Nitric oxide synthase, inducible

1

4

High-throughput

0.479

High

766463

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

767419

RADI
Radixin

1

1

High-throughput

0.479

High

880521

LMAN1
Protein ERGIC-53

1

3

High-throughput

0.479

High

883220

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

4

High-throughput

0.479

High

900778

RAB5C
Ras-related protein Rab-5C

1

7

High-throughput

0.479

High

901771

RAB9A
Ras-related protein Rab-9A

1

6

High-throughput

0.479

High

910015

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

925517

MOT1
Monocarboxylate transporter 1

1

10

High-throughput

0.479

High

936300

AFAD
Afadin

1

2

High-throughput

0.479

High

941773

ARL4C
ADP-ribosylation factor-like protein 4C

1

10

High-throughput

0.479

High

942563

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

953398

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955069

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

956257

RAB2A
Ras-related protein Rab-2A

1

10

High-throughput

0.479

High

961963

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

962712

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

963052

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

High-throughput

0.479

High

974989

ARF6
ADP-ribosylation factor 6

1

6

High-throughput

0.479

High

988290

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1014878

ARF1
ADP-ribosylation factor 1

1

6

High-throughput

0.479

High

1015374

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1031777

CAV1
Caveolin-1

1

3

High-throughput

0.479

High

1031781

STX4
Syntaxin-4

1

10

High-throughput

0.479

High

1031785

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

1

High-throughput

0.479

High

1031786

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1031788

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.479

High

1031792

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1031793

OCLN
Occludin

1

2

High-throughput

0.479

High

1031795

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.479

High

1031796

AR13B
ADP-ribosylation factor-like protein 13B

1

8

High-throughput

0.479

High

1031797

MIDN
Midnolin

1

1

High-throughput

0.479

High

1031804

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1031813

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1031817

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1031818

CXD3
Gap junction delta-3 protein

1

4

High-throughput

0.479

High

1031821

RN149
E3 ubiquitin-protein ligase RNF149

1

7

High-throughput

0.479

High

1031823

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

8

High-throughput

0.479

High

1031827

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.479

High

1031831

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1031832

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1031835

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.479

High

1031836

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.479

High

1031842

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

1031845

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

1031853

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.479

High

1031858

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

1031862

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

1031863

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1031866

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1031874

ELOV5
Very long chain fatty acid elongase 5

1

15

High-throughput

0.479

High

1031877

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

5

High-throughput

0.479

High

1031879

DNJ5B
DnaJ homolog subfamily C member 5B

1

1

High-throughput

0.479

High

1031880

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1031885

CLC4E
C-type lectin domain family 4 member E

1

4

High-throughput

0.479

High

1031888

LAMP3
Lysosome-associated membrane glycoprotein 3

1

8

High-throughput

0.479

High

128981

MEN1
Menin

1

0

High-throughput

0.458

High

154474

CLD4
Claudin-4

1

0

Small-scale

0.458

High

583290

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

861125

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

979516

H4
Histone H4

1

0

High-throughput

0.458

High

1031779

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1031784

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1031789

KS6A2
Ribosomal protein S6 kinase alpha-2

1

0

High-throughput

0.458

High

1031791

ELOB
Elongin-B

1

0

High-throughput

0.458

High

1031801

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1031803

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1031805

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1031807

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1031814

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1031822

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1031824

PARD3
Partitioning defective 3 homolog

1

0

High-throughput

0.458

High

1031833

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1031840

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1031844

TMX3
Protein disulfide-isomerase TMX3

1

0

High-throughput

0.458

High

1031847

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1031849

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1031864

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1031869

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1031870

ANLN
Anillin

1

0

High-throughput

0.458

High

1031871

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

1031876

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1031881

TES
Testin

1

0

High-throughput

0.458

High

1031890

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

1031891

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

62112

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

11

High-throughput

0.445

High

97245

E9PS44
Interferon induced transmembrane protein 3

1

2

High-throughput

0.445

High

163284

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

5

High-throughput

0.445

High

165568

SCAM3
Secretory carrier-associated membrane protein 3

1

5

High-throughput

0.445

High

169082

ML12B
Myosin regulatory light chain 12B

1

3

High-throughput

0.445

High

250085

ADCY9
Adenylate cyclase type 9

1

3

High-throughput

0.445

High

390542

TFR1
Transferrin receptor protein 1

1

2

High-throughput

0.445

High

463061

YES
Tyrosine-protein kinase Yes

1

6

High-throughput

0.445

High

641938

CD9
CD9 antigen

1

6

High-throughput

0.445

High

1031780

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

8

High-throughput

0.445

High

1031799

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

1031802

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

1031806

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

1

3

High-throughput

0.445

High

1031808

DPP8
Dipeptidyl peptidase 8

1

1

High-throughput

0.445

High

1031809

MPRIP
Myosin phosphatase Rho-interacting protein

1

1

High-throughput

0.445

High

1031820

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

5

High-throughput

0.445

High

1031826

SCFD1
Sec1 family domain-containing protein 1

1

9

High-throughput

0.445

High

1031834

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

2

High-throughput

0.445

High

1031843

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

3

High-throughput

0.445

High

1031846

B3GT6
Beta-1,3-galactosyltransferase 6

1

4

High-throughput

0.445

High

1031854

TMM59
Transmembrane protein 59

1

1

High-throughput

0.445

High

1031857

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.445

High

1031865

RN122
RING finger protein 122

1

8

High-throughput

0.445

High

1031867

SEC12
Guanine nucleotide-exchange factor SEC12

1

5

High-throughput

0.445

High

1031868

CHSTB
Carbohydrate sulfotransferase 11

1

1

High-throughput

0.445

High

1031883

LCAP
Leucyl-cystinyl aminopeptidase

1

2

High-throughput

0.445

High

1031884

AMFR
E3 ubiquitin-protein ligase AMFR

1

7

High-throughput

0.445

High

1031887

MYO6
Unconventional myosin-VI

1

2

High-throughput

0.445

High

293578

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

588491

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

695240

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

767982

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1004458

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.437

High

1031798

TM41B
Transmembrane protein 41B

1

3

High-throughput

0.437

High

1031810

M3K15
Mitogen-activated protein kinase kinase kinase 15

1

1

High-throughput

0.437

High

1031812

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1031816

TMM17
Transmembrane protein 17

1

3

High-throughput

0.437

High

1031838

PLD4
5'-3' exonuclease PLD4

1

1

High-throughput

0.437

High

773159

MYH10
Myosin-10

1

0

High-throughput

0.426

High

977677

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.426

High

1031775

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

1031778

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.426

High

1031790

ELOC
Elongin-C

1

0

High-throughput

0.426

High

1031860

F234A
Protein FAM234A

1

0

High-throughput

0.426

High

1031873

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.426

High

1031875

PDXL2
Podocalyxin-like protein 2

1

0

High-throughput

0.426

High

1031882

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.426

High

322137

GLCE
D-glucuronyl C5-epimerase

1

1

High-throughput

0.407

High

1031787

HERC3
Probable E3 ubiquitin-protein ligase HERC3

1

2

High-throughput

0.407

High

1031825

THEM6
Protein THEM6

1

1

High-throughput

0.407

High

1031837

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.407

High

1031839

EFHD2
EF-hand domain-containing protein D2

1

4

High-throughput

0.407

High

1031852

IFT27
Intraflagellar transport protein 27 homolog

1

11

High-throughput

0.407

High

622440

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.298

High

105774

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

139847

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

194144

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

352403

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

519102

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

1031848

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

1031872

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

1031889

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1031794

DREB
Drebrin

1

0

High-throughput

0.232

Low

1031851

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.232

Low

1031878

STX18
Syntaxin-18

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025