HitPredict

Interactor 1: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Interactor 2: TCPE (P48643)
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)
Gene: CCT5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	26496610, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 328 Hs			1 541
+	At
		138355 RAE1_ARATH (3-324): 5.63e-97: 292: 38.32		TCPE_ARATH (6-538): 0: 606: 68.29
+	Hs
		211135 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		TCPG_HUMAN (14-540): 0: 572: 33.15
+	Hs
		211236 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		TCPH_HUMAN (12-539): 0: 570: 29.64
+	Hs
		211118 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		TCPA_HUMAN (26-541): 0: 545: 32.08
+	Hs
		821437 NLE1_HUMAN (86-326): 2.9e-49: 172: 13.10		TCPE_HUMAN (1-541): 0: 635: 100.00
+	At
		1338309 BUB31_ARATH (1-327): 1.27e-85: 262: 51.80		TCPH_ARATH (12-540): 0: 542: 29.29
+	Hs
		821326 POC1B_HUMAN (134-327): 7.29e-41: 150: 13.93		TCPE_HUMAN (1-541): 0: 635: 100.00
+	At
		95566 BUB33_ARATH (1-316): 3.77e-75: 235: 32.08		TCPH_ARATH (12-540): 0: 542: 29.29
+	Hs
		154661 GNB5_HUMAN (13-206): 2.53e-26: 109: 22.06		TCPE_HUMAN (1-541): 0: 635: 100.00
+	Hs
		1306704 NLE1_HUMAN (86-326): 2.9e-49: 172: 13.10		TCPH_HUMAN (12-539): 0: 570: 29.64
+	Hs
		826807 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		TCPG_HUMAN (14-540): 0: 572: 33.15
+	Hs
		826784 POC1B_HUMAN (134-327): 7.29e-41: 150: 13.93		TCPG_HUMAN (14-540): 0: 572: 33.15
+	Hs
		573406 FBXW7_HUMAN (1-202): 6.93e-47: 169: 20.85		TCPA_HUMAN (26-541): 0: 545: 32.08
+	Hs
		573384 POC1B_HUMAN (134-327): 7.29e-41: 150: 13.93		TCPA_HUMAN (26-541): 0: 545: 32.08
+	Hs
		792942 LIS1_HUMAN (168-319): 3.74e-31: 122: 14.47		TCPG_HUMAN (14-540): 0: 572: 33.15
+	Hs
		154653 GNB5_HUMAN (13-206): 2.53e-26: 109: 22.06		TCPA_HUMAN (26-541): 0: 545: 32.08
+	Hs
		211141 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80
+	At
		1105260 RAE1_ARATH (3-324): 5.63e-97: 292: 38.32		TCPD_ARATH (36-533): 1.54e-103: 323: 40.04
+	Hs
		843411 NLE1_HUMAN (86-326): 2.9e-49: 172: 13.10		TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80
+	Hs
		843299 POC1B_HUMAN (134-327): 7.29e-41: 150: 13.93		TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80