HitPredict

Interactor 1: BUB3 (O43684)
Mitotic checkpoint protein BUB3
Gene: BUB3

Interactor 2: CDC23 (Q9UJX2)
Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Cyclosome subunit 8)
Gene: CDC23

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	28514442, 33961781, 20360068
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 328 Hs			1 597
+	Sc
		454912 GLE2_YEAST (5-326): 1.95e-94: 286: 34.22		CDC16_YEAST (67-589): 9.77e-57: 206: 18.02
+	Ca
		483035 TUP1_CANAL (1-206): 8.77e-55: 188: 17.18		Q5ADP3_CANAL (36-448): 1.56e-50: 190: 15.95
+	Hs
		211167 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		CDC16_HUMAN (135-590): 4.3e-15: 80.6: 10.41
+	Hs
		211124 BUB3_HUMAN (1-328): 4.65e-94: 284: 100.00		CDC27_HUMAN (25-264): 2.24e-11: 69.1: 8.71
+	Sp
		224207 TUP11_SCHPO (1-213): 6.22e-64: 214: 17.90		CYC8_SCHPO (15-269): 5.96e-16: 83.7: 10.43
+	Hs
		174768 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		OGT1_HUMAN (296-593): 1.55e-47: 181: 14.77
+	Mm
		1246853 FBXW7_MOUSE (1-202): 1.89e-47: 171: 20.85		CDC16_MOUSE (135-590): 5.99e-15: 79.9: 10.46
+	Sp
		224208 TUP12_SCHPO (170-318): 3.04e-26: 110: 17.45		CYC8_SCHPO (15-269): 5.96e-16: 83.7: 10.43
+	Hs
		903589 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		APC7_HUMAN (220-575): 2.97e-13: 74.5: 10.62
+	Hs
		672800 WDR5_HUMAN (209-320): 6.93e-20: 90.4: 16.07		CDC27_HUMAN (25-264): 2.24e-11: 69.1: 8.71