Protein: SAFB1
Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein)

Gene: SAFB1, SAFB
Organism: Homo sapiens
Interactions: 205
UniProt ID: Q15424

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003682 - chromatin binding
GO:0003690 - double-stranded DNA binding
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

485160

ROA1
Heterogeneous nuclear ribonucleoprotein A1

4

20

Small-scale

0.890

High

775105

FUS
RNA-binding protein FUS

3

20

Small-scale

0.865

High

1121675

SAFB2
Scaffold attachment factor B2

2

18

Small-scale

0.815

High

1148453

RBP56
TATA-binding protein-associated factor 2N

2

12

Small-scale

0.815

High

1088362

CHD3
Chromodomain-helicase-DNA-binding protein 3

2

12

High-throughput

0.793

High

1148463

SRPK1
SRSF protein kinase 1

2

20

Small-scale

0.783

High

1090229

ELAV2
ELAV-like protein 2

2

19

High-throughput

0.776

High

1148475

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

2

5

High-throughput

0.737

High

1148449

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

8

Small-scale

0.724

High

997732

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.710

High

443376

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.691

High

478058

SNRPA
U1 small nuclear ribonucleoprotein A

1

18

High-throughput

0.691

High

794497

RBMX
RNA-binding motif protein, X chromosome

1

20

High-throughput

0.691

High

879721

MAPK2
MAP kinase-activated protein kinase 2

1

2

High-throughput

0.691

High

1100794

G3BP1
Ras GTPase-activating protein-binding protein 1

1

20

High-throughput

0.691

High

1115673

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

13

High-throughput

0.691

High

1119635

KGP1
cGMP-dependent protein kinase 1

1

10

High-throughput

0.691

High

1148420

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

15

High-throughput

0.691

High

1148461

RBM14
RNA-binding protein 14

1

18

High-throughput

0.691

High

1148467

RBM4B
RNA-binding protein 4B

1

19

High-throughput

0.691

High

1120163

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

19

Small-scale

0.680

High

396170

ESR1
Estrogen receptor

3

20

Small-scale

0.667

High

1006421

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.647

High

372100

MYC
Myc proto-oncogene protein

3

16

High-throughput

0.640

High

278354

NCOR1
Nuclear receptor corepressor 1

2

8

Small-scale

0.631

High

889426

CLK1
Dual specificity protein kinase CLK1

1

20

Small-scale

0.621

High

170152

AURKA
Aurora kinase A

1

12

High-throughput

0.618

High

472756

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

17

High-throughput

0.618

High

897829

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.618

High

986442

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.618

High

1032986

EWS
RNA-binding protein EWS

1

12

High-throughput

0.618

High

1099923

TIF1B
Transcription intermediary factor 1-beta

1

14

Small-scale

0.618

High

1126904

RBM39
RNA-binding protein 39

1

19

High-throughput

0.618

High

1132712

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

12

High-throughput

0.618

High

1148484

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.618

High

1148489

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

4

Small-scale

0.618

High

846314

MATR3
Matrin-3

2

11

High-throughput

0.611

High

1148429

IFIX
Pyrin and HIN domain-containing protein 1

2

12

High-throughput

0.611

High

480148

RU1C
U1 small nuclear ribonucleoprotein C

2

3

High-throughput

0.601

High

1148474

MLP3B
Microtubule-associated protein 1 light chain 3 beta

3

15

High-throughput

0.590

High

188284

HDAC3
Histone deacetylase 3

2

6

Small-scale

0.584

High

259992

BRD4
Bromodomain-containing protein 4

2

11

High-throughput

0.584

High

1004601

RNF4
E3 ubiquitin-protein ligase RNF4

2

2

Small-scale

0.584

High

1148480

ANLN
Anillin

2

7

High-throughput

0.584

High

911596

NCBP2
Nuclear cap-binding protein subunit 2

1

19

High-throughput

0.575

High

1016454

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.575

High

1066654

NCBP1
Nuclear cap-binding protein subunit 1

1

4

High-throughput

0.575

High

1148425

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

Small-scale

0.575

High

1148487

ZN346
Zinc finger protein 346

1

3

High-throughput

0.575

High

1148447

RBCC1
RB1-inducible coiled-coil protein 1

2

15

High-throughput

0.558

High

157414

CTRO
Citron Rho-interacting kinase

1

14

High-throughput

0.553

High

1148462

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

3

High-throughput

0.549

High

166157

AIM2
Interferon-inducible protein AIM2

1

12

High-throughput

0.536

High

272663

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

11

High-throughput

0.536

High

471038

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.536

High

481291

HMGB1
High mobility group protein B1

1

20

High-throughput

0.536

High

542041

TOP1
DNA topoisomerase 1

1

4

High-throughput

0.536

High

574281

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

4

High-throughput

0.536

High

640894

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

4

High-throughput

0.536

High

788035

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.536

High

948529

APC15
Anaphase-promoting complex subunit 15

1

2

High-throughput

0.536

High

968313

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

13

High-throughput

0.536

High

1065213

SSRP1
FACT complex subunit SSRP1

1

13

High-throughput

0.536

High

1113175

CUL3
Cullin-3

1

20

High-throughput

0.536

High

1142779

PEA15
Astrocytic phosphoprotein PEA-15

1

3

High-throughput

0.536

High

1148422

IF16
Gamma-interferon-inducible protein 16

1

12

High-throughput

0.536

High

1148432

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

2

High-throughput

0.536

High

1148433

COX15
Heme A synthase COX15

1

3

High-throughput

0.536

High

1148465

MPP8
M-phase phosphoprotein 8

1

11

High-throughput

0.536

High

1148476

P63
Tumor protein 63

1

7

Small-scale

0.536

High

1148481

DDX21
Nucleolar RNA helicase 2

1

9

High-throughput

0.536

High

413887

P53
Cellular tumor antigen p53

1

7

Small-scale

0.534

High

440085

LCK
Tyrosine-protein kinase Lck

2

7

High-throughput

0.521

High

1148477

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

2

15

Small-scale

0.521

High

352447

TOP3B
DNA topoisomerase 3-beta-1

1

2

High-throughput

0.515

High

459295

CATL1
Procathepsin L

1

2

High-throughput

0.515

High

532603

CH60
60 kDa heat shock protein, mitochondrial

1

5

High-throughput

0.515

High

1148445

KRI1
Protein KRI1 homolog

1

1

High-throughput

0.515

High

964299

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

641180

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.500

High

135627

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.489

High

271529

ATG13
Autophagy-related protein 13

1

3

High-throughput

0.489

High

457095

CAN1
Calpain-1 catalytic subunit

1

5

High-throughput

0.489

High

515884

SAA1
Serum amyloid A-1 protein

1

2

High-throughput

0.489

High

711897

LTK
Leukocyte tyrosine kinase receptor

1

15

High-throughput

0.489

High

1148430

CAN13
Calpain-13

1

5

High-throughput

0.489

High

1148456

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

2

High-throughput

0.489

High

1148458

ERLEC
Endoplasmic reticulum lectin 1

1

1

High-throughput

0.489

High

1148468

ATGA1
Autophagy-related protein 101

1

1

High-throughput

0.489

High

1148492

KLH20
Kelch-like protein 20

1

4

High-throughput

0.489

High

160091

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

12

Small-scale

0.481

High

129107

MEN1
Menin

1

5

High-throughput

0.479

High

132059

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

188893

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.479

High

223070

PRC1
Protein regulator of cytokinesis 1

1

7

High-throughput

0.479

High

241761

PRKN
E3 ubiquitin-protein ligase parkin

1

17

High-throughput

0.479

High

247924

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

285300

EED
Polycomb protein EED

1

15

High-throughput

0.479

High

297616

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

Small-scale

0.479

High

330993

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

345863

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.479

High

406210

MYCN
N-myc proto-oncogene protein

1

15

High-throughput

0.479

High

482483

F16P1
Fructose-1,6-bisphosphatase 1

1

2

High-throughput

0.479

High

537204

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

588773

RFA2
Replication protein A 32 kDa subunit

1

13

High-throughput

0.479

High

629887

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

657583

GCSP
Glycine dehydrogenase

1

2

High-throughput

0.479

High

695538

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

714141

PML
Protein PML

1

16

High-throughput

0.479

High

714867

EF1D
Elongation factor 1-delta

1

1

High-throughput

0.479

High

768267

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

851569

GATA4
Transcription factor GATA-4

1

3

High-throughput

0.479

High

854859

RECQ1
ATP-dependent DNA helicase Q1

1

8

High-throughput

0.479

High

879122

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

10

High-throughput

0.479

High

904751

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

937759

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

970554

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

979704

H4
Histone H4

1

9

High-throughput

0.479

High

983817

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

High-throughput

0.479

High

1035641

KIF23
Kinesin-like protein KIF23

1

18

High-throughput

0.479

High

1067360

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

1085560

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.479

High

1088849

TP53B
TP53-binding protein 1

1

6

High-throughput

0.479

High

1096698

RFA4
Replication protein A 30 kDa subunit

1

13

High-throughput

0.479

High

1106903

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1115205

CUL4B
Cullin-4B

1

20

High-throughput

0.479

High

1128010

DHX8
ATP-dependent RNA helicase DHX8

1

6

High-throughput

0.479

High

1137708

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

1140315

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1148421

FSCN1
Fascin

1

1

High-throughput

0.479

High

1148426

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

14

High-throughput

0.479

High

1148434

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1148435

BIVM
Basic immunoglobulin-like variable motif-containing protein

1

1

High-throughput

0.479

High

1148437

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1148438

ZCH18
Zinc finger CCCH domain-containing protein 18

1

11

High-throughput

0.479

High

1148439

DHX40
Probable ATP-dependent RNA helicase DHX40

1

6

High-throughput

0.479

High

1148440

SMC5
Structural maintenance of chromosomes protein 5

1

9

High-throughput

0.479

High

1148441

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

1148442

SRRM1
Serine/arginine repetitive matrix protein 1

1

5

High-throughput

0.479

High

1148443

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

5

High-throughput

0.479

High

1148444

ZFP41
Zinc finger protein 41 homolog

1

4

High-throughput

0.479

High

1148446

NUP43
Nucleoporin Nup43

1

5

High-throughput

0.479

High

1148448

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1148451

TOPB1
DNA topoisomerase 2-binding protein 1

1

7

High-throughput

0.479

High

1148452

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1148454

FUBP1
Far upstream element-binding protein 1

1

20

High-throughput

0.479

High

1148457

CHM4C
Charged multivesicular body protein 4c

1

10

High-throughput

0.479

High

1148466

ANM1
Protein arginine N-methyltransferase 1

1

8

High-throughput

0.479

High

1148469

DDX23
Probable ATP-dependent RNA helicase DDX23

1

8

High-throughput

0.479

High

1148471

FACD2
Fanconi anemia group D2 protein

1

11

High-throughput

0.479

High

1148482

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1148485

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

1148491

FBW1A
F-box/WD repeat-containing protein 1A

1

10

High-throughput

0.479

High

353349

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.470

High

488796

FURIN
Furin

1

1

High-throughput

0.470

High

1148464

STAC
SH3 and cysteine-rich domain-containing protein

1

8

High-throughput

0.470

High

1148472

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.470

High

390587

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

587476

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

1096552

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

1056744

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.457

High

1088184

MERTK
Tyrosine-protein kinase Mer

1

14

High-throughput

0.457

High

1148483

EPHA6
Ephrin type-A receptor 6

1

17

High-throughput

0.457

High

429938

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

520071

ANDR
Androgen receptor

1

20

Small-scale

0.445

High

529851

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.445

High

1119137

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

9

High-throughput

0.445

High

1148423

NCBP3
Nuclear cap-binding protein subunit 3

1

5

High-throughput

0.445

High

1148424

ODFP2
Outer dense fiber protein 2

1

2

High-throughput

0.445

High

1148436

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

2

High-throughput

0.445

High

1148455

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

18

High-throughput

0.445

High

1148459

THOC1
THO complex subunit 1

1

1

Small-scale

0.445

High

1148486

DDX41
Probable ATP-dependent RNA helicase DDX41

1

4

High-throughput

0.445

High

1148493

CHTOP
Chromatin target of PRMT1 protein

1

1

High-throughput

0.445

High

164347

NRP1
Neuropilin-1

1

2

High-throughput

0.437

High

272207

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.437

High

273626

PHAR2
Phosphatase and actin regulator 2

1

4

High-throughput

0.437

High

375544

RASK
GTPase KRas

1

3

High-throughput

0.437

High

411983

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.437

High

774373

BASI
Basigin

1

6

High-throughput

0.437

High

936054

PAR2
Proteinase-activated receptor 2

1

2

High-throughput

0.437

High

959169

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.437

High

1134903

CUL7
Cullin-7

1

8

High-throughput

0.437

High

1148427

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.437

High

1148428

Q6ICH2
single-stranded DNA cytosine deaminase

1

18

High-throughput

0.437

High

1148431

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1148450

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

1148473

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

7

High-throughput

0.437

High

1148478

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.437

High

1148490

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.437

High

1108344

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.426

High

886882

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.408

High

87465

OSCRI
SCRIB overlapping open reading frame protein

1

2

High-throughput

0.407

High

255037

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.407

High

1138835

SYLM
Leucine--tRNA ligase, mitochondrial

1

1

High-throughput

0.407

High

1148479

GHC1
Mitochondrial glutamate carrier 1

1

2

High-throughput

0.407

High

1148488

PNMA2
Paraneoplastic antigen Ma2

1

6

High-throughput

0.407

High

1148460

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

800212

VKGC
Vitamin K-dependent gamma-carboxylase

1

0

High-throughput

0.269

Low

844782

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.269

Low

350368

ABHGA
Phosphatidylserine lipase ABHD16A

1

0

Small-scale

0.265

Low

1148419

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.265

Low

692977

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.249

Low

1148470

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

1148418

UT2
Urea transporter 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025