HitPredict

Interactor 1: ACTN4 (O43707)
Alpha-actinin-4 (Non-muscle alpha-actinin 4)
Gene: ACTN4

Interactor 2: DAPK1 (P53355)
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Gene: DAPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0015629 - actin cytoskeleton GO:0042981 - regulation of apoptotic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 911 Hs			1 1430
+	Hs
		521508 ACTN1_HUMAN (20-911): 0: 607: 85.76		DAPK1_HUMAN (1-1430): 0: 1999: 100.00
+	Hs
		862027 SPTB2_HUMAN (215-825): 5.91e-11: 68.9: 10.75		DAPK1_HUMAN (1-1430): 0: 1999: 100.00
+	Hs
		164586 SPTN2_HUMAN (262-846): 1.08e-09: 64.7: 12.62		DAPK1_HUMAN (1-1430): 0: 1999: 100.00
+	Rn
		506781 ACTN1_RAT (20-911): 0: 608: 85.99		KCC2A_RAT (1-383): 5.07e-120: 385: 29.17
+	Hs
		521641 ACTN1_HUMAN (20-911): 0: 607: 85.76		KCC2A_HUMAN (1-383): 6.29e-120: 385: 29.17
+	Hs
		211695 ACTN4_HUMAN (1-911): 0: 586: 100.00		KCC2A_HUMAN (1-383): 6.29e-120: 385: 29.17
+	Mm
		515254 ACTN2_MOUSE (19-911): 0: 558: 77.49		KCC2A_MOUSE (1-383): 5.07e-120: 385: 29.17
+	Rn
		88556 D3ZCV0_RAT (32-911): 0: 554: 77.87		KCC2A_RAT (1-383): 5.07e-120: 385: 29.17
+	Hs
		963292 SPTB2_HUMAN (215-825): 5.91e-11: 68.9: 10.75		ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42
+	Hs
		164604 SPTN2_HUMAN (262-846): 1.08e-09: 64.7: 12.62		ANK2_HUMAN (248-797): 3.54e-109: 385: 19.42
+	Mm
		103598 Q3UGX2_MOUSE (240-817): 2.23e-09: 63.9: 11.64		ANK3_MOUSE (518-936): 2.88e-74: 276: 16.06
+	Mm
		103603 SPTB2_MOUSE (285-829): 1.98e-09: 63.9: 11.15		ANK3_MOUSE (518-936): 2.88e-74: 276: 16.06
+	Hs
		556695 SPTB2_HUMAN (215-825): 5.91e-11: 68.9: 10.75		ANK1_HUMAN (503-915): 9.04e-72: 267: 15.66
+	Hs
		506803 SPTB1_HUMAN (213-819): 7.03e-09: 62: 10.57		ANK1_HUMAN (503-915): 9.04e-72: 267: 15.66
+	Mm
		57856 Q68FG2_MOUSE (262-812): 5.17e-11: 68.9: 12.14		KALRN_MOUSE (2-312): 1.12e-61: 236: 38.91
+	Mm
		57853 SPTB2_MOUSE (285-829): 1.98e-09: 63.9: 11.15		KALRN_MOUSE (2-312): 1.12e-61: 236: 38.91
+	Hs
		1021458 SPTN4_HUMAN (244-822): 1.07e-13: 77.8: 11.00		ANK3_HUMAN (737-962): 6.16e-11: 69.6: 12.16
+	Hs
		963306 SPTB2_HUMAN (215-825): 5.91e-11: 68.9: 10.75		ANK3_HUMAN (737-962): 6.16e-11: 69.6: 12.16
+	Hs
		164611 SPTN2_HUMAN (262-846): 1.08e-09: 64.7: 12.62		ANK3_HUMAN (737-962): 6.16e-11: 69.6: 12.16