Protein: SIAH1
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)

Gene: SIAH1
Organism: Homo sapiens
Interactions: 233
UniProt ID: Q8IUQ4

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1307740

SIAH1
E3 ubiquitin-protein ligase SIAH1

13

16

Small-scale

0.980

High

211577

SIAH2
E3 ubiquitin-protein ligase SIAH2

4

17

Small-scale

0.910

High

1307799

CYBP
Calcyclin-binding protein

8

3

Small-scale

0.755

High

982237

UB2D2
Ubiquitin-conjugating enzyme E2 D2

6

20

Small-scale

0.733

High

1307794

HIPK2
Homeodomain-interacting protein kinase 2

5

13

Small-scale

0.732

High

957129

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

20

Small-scale

0.719

High

906700

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.714

High

791513

SYUA
Alpha-synuclein

4

3

Small-scale

0.712

High

1307742

PHC2
Polyhomeotic-like protein 2

4

5

Small-scale

0.707

High

322964

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

4

10

Small-scale

0.705

High

764875

CTNB1
Catenin beta-1

5

4

Small-scale

0.704

High

1307812

PUF60
Poly(U)-binding-splicing factor PUF60

4

3

Small-scale

0.698

High

714910

EF1D
Elongation factor 1-delta

3

1

Small-scale

0.682

High

957626

UBE2K
Ubiquitin-conjugating enzyme E2 K

3

20

High-throughput

0.680

High

408971

G3P
Glyceraldehyde-3-phosphate dehydrogenase

4

3

Small-scale

0.676

High

284691

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

3

3

Small-scale

0.667

High

484591

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

3

1

High-throughput

0.667

High

1307817

MARE3
Microtubule-associated protein RP/EB family member 3

3

4

Small-scale

0.665

High

1307825

SNCAP
Synphilin-1

2

8

Small-scale

0.660

High

1307765

R51A1
RAD51-associated protein 1

3

0

High-throughput

0.646

High

889302

NUMB
Protein numb homolog

2

5

Small-scale

0.646

High

325242

UPP2
Uridine phosphorylase 2

2

2

High-throughput

0.646

High

1287192

PEG10
Retrotransposon-derived protein PEG10

2

1

Small-scale

0.641

High

181138

AXIN1
Axin-1

2

2

Small-scale

0.640

High

1115552

ASPP2
Apoptosis-stimulating of p53 protein 2

2

11

High-throughput

0.633

High

1307774

CTIP
DNA endonuclease RBBP8

2

1

Small-scale

0.631

High

1307775

MYD88
Myeloid differentiation primary response protein MyD88

2

7

Small-scale

0.631

High

1307759

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

0

High-throughput

0.626

High

1095092

KLF10
Krueppel-like factor 10

2

3

Small-scale

0.625

High

1307769

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

20

Small-scale

0.624

High

1060797

ACK1
Activated CDC42 kinase 1

2

11

Small-scale

0.619

High

1307819

AXIN2
Axin-2

2

2

Small-scale

0.619

High

1017717

PR20A
Proline-rich protein 20A

4

5

High-throughput

0.618

High

1307741

SIAH3
Seven in absentia homolog 3

1

11

Small-scale

0.618

High

1022742

XIAP
E3 ubiquitin-protein ligase XIAP

2

7

Small-scale

0.612

High

297647

PIAS1
E3 SUMO-protein ligase PIAS1

2

8

Small-scale

0.606

High

336712

BAG4
BAG family molecular chaperone regulator 4

2

1

High-throughput

0.606

High

347793

BAG3
BAG family molecular chaperone regulator 3

2

1

High-throughput

0.606

High

1218278

SMBT2
Scm-like with four MBT domains protein 2

2

5

High-throughput

0.606

High

1307776

BAG1
BAG family molecular chaperone regulator 1

2

0

Small-scale

0.605

High

1096584

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

2

0

Small-scale

0.598

High

928299

ATN1
Atrophin-1

2

4

High-throughput

0.595

High

827834

STAT3
Signal transducer and activator of transcription 3

2

1

Small-scale

0.586

High

845978

DCC
Netrin receptor DCC

2

1

Small-scale

0.586

High

1307762

CSN5
COP9 signalosome complex subunit 5

2

1

Small-scale

0.586

High

1149923

TERF2
Telomeric repeat-binding factor 2

2

0

Small-scale

0.585

High

993644

UBC9
SUMO-conjugating enzyme UBC9

2

20

Small-scale

0.584

High

1307753

M1AP
Meiosis 1 arrest protein

2

0

High-throughput

0.580

High

1307803

LANC2
LanC-like protein 2

2

0

High-throughput

0.580

High

1307773

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

12

Small-scale

0.578

High

1307811

AFF4
AF4/FMR2 family member 4

2

9

High-throughput

0.578

High

137335

ELL2
RNA polymerase II elongation factor ELL2

2

1

Small-scale

0.575

High

286390

DAB1
Disabled homolog 1

1

5

Small-scale

0.573

High

1132619

KIF22
Kinesin-like protein KIF22

1

3

Small-scale

0.573

High

140342

SDCB1
Syntenin-1

1

4

High-throughput

0.573

High

220662

SYT7
Synaptotagmin-7

1

2

High-throughput

0.573

High

246023

KIF1B
Kinesin-like protein KIF1B

1

5

High-throughput

0.573

High

246251

MABP1
Mitogen-activated protein kinase-binding protein 1

1

3

High-throughput

0.573

High

572053

TRI27
Zinc finger protein RFP

1

8

High-throughput

0.573

High

633385

MX1
Interferon-induced GTP-binding protein Mx1

1

1

High-throughput

0.573

High

783320

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.573

High

832744

BCL6
B-cell lymphoma 6 protein

1

5

High-throughput

0.573

High

883274

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

20

High-throughput

0.573

High

923359

MK12
Mitogen-activated protein kinase 12

1

7

High-throughput

0.573

High

979937

H4
Histone H4

1

1

High-throughput

0.573

High

1030964

FLI1
Friend leukemia integration 1 transcription factor

1

1

High-throughput

0.573

High

1103818

MB211
Putative nucleotidyltransferase MAB21L1

1

1

High-throughput

0.573

High

1180154

QRIC1
Transcriptional regulator QRICH1

1

2

High-throughput

0.573

High

1307756

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

1

High-throughput

0.573

High

1307757

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

1

High-throughput

0.573

High

1307758

ZCH13
Zinc finger CCHC domain-containing protein 13

1

2

High-throughput

0.573

High

1307766

OTUB2
Ubiquitin thioesterase OTUB2

1

2

High-throughput

0.573

High

1307767

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

4

High-throughput

0.573

High

1307768

Z512B
Zinc finger protein 512B

1

4

High-throughput

0.573

High

1307777

ZFY21
Zinc finger FYVE domain-containing protein 21

1

4

High-throughput

0.573

High

1307782

KATL1
Katanin p60 ATPase-containing subunit A-like 1

1

1

High-throughput

0.573

High

1307786

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

7

High-throughput

0.573

High

1307795

NELFA
Negative elongation factor A

1

1

High-throughput

0.573

High

1307813

DDX41
Probable ATP-dependent RNA helicase DDX41

1

3

High-throughput

0.573

High

1307814

CDC23
Cell division cycle protein 23 homolog

1

3

High-throughput

0.573

High

1307818

ZN148
Zinc finger protein 148

1

5

High-throughput

0.573

High

1307822

ARIP4
Helicase ARIP4

1

2

High-throughput

0.573

High

668650

APC
Adenomatous polyposis coli protein

1

6

Small-scale

0.561

High

905436

HCFC1
Host cell factor 1

1

2

Small-scale

0.561

High

1307783

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

7

Small-scale

0.561

High

1307824

HCFC2
Host cell factor 2

1

2

Small-scale

0.561

High

1307788

RB33B
Ras-related protein Rab-33B

2

2

High-throughput

0.553

High

184726

ATX7
Ataxin-7

1

3

High-throughput

0.552

High

835444

GRM5
Metabotropic glutamate receptor 5

1

2

Small-scale

0.552

High

1022587

PKD1
Polycystin-1

1

2

Small-scale

0.552

High

1307771

TRIB3
Tribbles homolog 3

1

2

Small-scale

0.552

High

1307787

PEG3
Paternally-expressed gene 3 protein

1

1

Small-scale

0.552

High

159988

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.549

High

467936

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

0

High-throughput

0.549

High

539553

PYGB
Glycogen phosphorylase, brain form

1

0

High-throughput

0.549

High

715926

AQP1
Aquaporin-1

1

0

High-throughput

0.549

High

818749

CAPG
Macrophage-capping protein

1

0

High-throughput

0.549

High

1199900

LACB2
Endoribonuclease LACTB2

1

0

High-throughput

0.549

High

1212997

SKT
Sickle tail protein homolog

1

0

High-throughput

0.549

High

1258341

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.549

High

1277076

ARMC9
LisH domain-containing protein ARMC9

1

0

High-throughput

0.549

High

1292957

AROS
Active regulator of SIRT1

1

0

High-throughput

0.549

High

1307747

SPAT4
Spermatogenesis-associated protein 4

1

0

High-throughput

0.549

High

1307752

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.549

High

1307789

SPC1L
Speriolin-like protein

1

0

High-throughput

0.549

High

1307790

IQCN
IQ domain-containing protein N

1

0

High-throughput

0.549

High

1307798

ZMAT3
Zinc finger matrin-type protein 3

1

0

High-throughput

0.549

High

1307802

ADPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

1

0

High-throughput

0.549

High

1307810

UXT
Protein UXT

1

0

High-throughput

0.549

High

704540

RXRB
Retinoic acid receptor RXR-beta

1

7

High-throughput

0.541

High

957785

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.541

High

1154122

ITSN1
Intersectin-1

1

1

High-throughput

0.541

High

1154274

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

High-throughput

0.541

High

1307785

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

12

High-throughput

0.541

High

1307820

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.541

High

1139078

DAZP2
DAZ-associated protein 2

1

0

Small-scale

0.537

High

1307808

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

Small-scale

0.537

High

1307784

PAR6B
Partitioning defective 6 homolog beta

1

0

High-throughput

0.536

High

440622

FYN
Tyrosine-protein kinase Fyn

1

3

High-throughput

0.536

High

770881

OPRM
Mu-type opioid receptor

1

7

Small-scale

0.535

High

908281

AFF1
AF4/FMR2 family member 1

1

9

Small-scale

0.535

High

1120111

RB33A
Ras-related protein Rab-33A

1

2

High-throughput

0.523

High

1295057

F90A1
Protein FAM90A1

1

1

High-throughput

0.523

High

1307760

NECT2
Nectin-2

1

2

High-throughput

0.523

High

1307781

KIFC3
Kinesin-like protein KIFC3

1

2

High-throughput

0.523

High

1307804

TB22B
TBC1 domain family member 22B

1

1

High-throughput

0.523

High

832386

OPRK
Kappa-type opioid receptor

1

7

Small-scale

0.515

High

1307754

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

11

High-throughput

0.515

High

278380

NCOR1
Nuclear receptor corepressor 1

1

6

High-throughput

0.515

High

422502

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.515

High

877166

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.515

High

927399

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

1055331

APLP2
Amyloid beta precursor like protein 2

1

5

High-throughput

0.515

High

1096086

TADBP
TAR DNA-binding protein 43

1

9

High-throughput

0.515

High

1202591

Q59GP6
Polyhomeotic-like protein 1 variant

1

6

High-throughput

0.515

High

1232788

Q6FIE9
Toll-interacting protein

1

3

High-throughput

0.515

High

1289857

Q86V38
Atrophin 1

1

5

High-throughput

0.515

High

1307745

Q8N619
Cyclin-dependent kinase 5 activator

1

2

High-throughput

0.515

High

1307748

Q8TAM4
Cyclin-dependent kinase 5 activator

1

2

High-throughput

0.515

High

1307761

KLK6
Kallikrein-6

1

1

High-throughput

0.515

High

249630

SNX3
Sorting nexin-3

1

0

High-throughput

0.513

High

787042

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

1

Small-scale

0.512

High

210499

SEPT4
Septin-4

1

0

Small-scale

0.512

High

1307796

HIPK3
Homeodomain-interacting protein kinase 3

1

15

High-throughput

0.508

High

1150447

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

5

Small-scale

0.506

High

1243820

CTR9
RNA polymerase-associated protein CTR9 homolog

1

3

Small-scale

0.504

High

1017597

PR20E
Proline-rich protein 20E

2

5

High-throughput

0.504

High

168547

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

Small-scale

0.501

High

1156135

ZYX
Zyxin

1

6

Small-scale

0.501

High

1307827

PIAS3
E3 SUMO-protein ligase PIAS3

1

8

Small-scale

0.501

High

1307815

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

2

High-throughput

0.489

High

123002

FZD9
Frizzled-9

1

3

High-throughput

0.481

High

297835

PIAS2
E3 SUMO-protein ligase PIAS2

1

8

Small-scale

0.481

High

385929

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.481

High

584563

VAV
Proto-oncogene vav

1

2

Small-scale

0.481

High

858979

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.481

High

1006855

PHC1
Polyhomeotic-like protein 1

1

5

High-throughput

0.481

High

1122841

TFDP1
Transcription factor Dp-1

1

1

High-throughput

0.481

High

1142246

CD5R1
Cyclin-dependent kinase 5 activator 1

1

2

High-throughput

0.481

High

1258030

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

2

High-throughput

0.481

High

1307750

ZN671
Zinc finger protein 671

1

1

High-throughput

0.481

High

1307763

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

Small-scale

0.481

High

1307791

TOLIP
Toll-interacting protein

1

3

High-throughput

0.481

High

1307792

ZBP1
Z-DNA-binding protein 1

1

2

High-throughput

0.481

High

1307826

NUMBL
Numb-like protein

1

6

High-throughput

0.481

High

186770

P73
Tumor protein p73

1

2

Small-scale

0.479

High

251616

CCNT1
Cyclin-T1

1

2

Small-scale

0.479

High

261422

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

4

Small-scale

0.479

High

466583

TNR16
Tumor necrosis factor receptor superfamily member 16

1

20

Small-scale

0.479

High

520603

RARA
Retinoic acid receptor alpha

1

8

Small-scale

0.479

High

714246

PML
Protein PML

1

11

Small-scale

0.479

High

790065

ZEB1
Zinc finger E-box-binding homeobox 1

1

5

Small-scale

0.479

High

857340

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

1

Small-scale

0.479

High

857494

NOTC1
Neurogenic locus notch homolog protein 1

1

3

Small-scale

0.479

High

861673

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

6

Small-scale

0.479

High

862276

YAP1
Transcriptional coactivator YAP1

1

7

Small-scale

0.479

High

888175

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

904902

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

968981

PRS8
26S proteasome regulatory subunit 8

1

1

Small-scale

0.479

High

975449

PRS10
26S proteasome regulatory subunit 10B

1

1

Small-scale

0.479

High

994639

YBOX1
Y-box-binding protein 1

1

2

Small-scale

0.479

High

1083399

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

1

Small-scale

0.479

High

1113616

CUL3
Cullin-3

1

9

High-throughput

0.479

High

1280030

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

13

Small-scale

0.479

High

1295738

HIPK1
Homeodomain-interacting protein kinase 1

1

15

Small-scale

0.479

High

1307755

PARD3
Partitioning defective 3 homolog

1

11

Small-scale

0.479

High

1307772

RING2
E3 ubiquitin-protein ligase RING2

1

13

High-throughput

0.479

High

1307780

TRAF4
TNF receptor-associated factor 4

1

18

Small-scale

0.479

High

1307801

LATS2
Serine/threonine-protein kinase LATS2

1

7

Small-scale

0.479

High

1307806

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

Small-scale

0.479

High

1307809

PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

1

2

Small-scale

0.479

High

1307816

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.479

High

60224

A2RRL9
Z-DNA-binding protein 1

1

2

High-throughput

0.470

High

1017615

PR20C
Proline-rich protein 20C

1

5

High-throughput

0.470

High

1017649

PR20D
Proline-rich protein 20D

1

5

High-throughput

0.470

High

1307749

Q8TAN2
Frizzled homolog 9

1

3

High-throughput

0.470

High

1307764

COQA1
Collagen alpha-1(XXVI) chain

1

1

High-throughput

0.470

High

528296

THIO
Thioredoxin

1

0

High-throughput

0.460

High

1307746

SLAI1
SLAIN motif-containing protein 1

1

0

Small-scale

0.460

High

447191

NPM
Nucleophosmin

1

0

Small-scale

0.458

High

843735

HD
Huntingtin

1

0

Small-scale

0.458

High

1029873

RUNX1
Runt-related transcription factor 1

1

0

Small-scale

0.458

High

1136658

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

Small-scale

0.458

High

1307807

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

469510

SYPH
Synaptophysin

1

2

Small-scale

0.457

High

3350

A0A0S2Z4M1
Axin-1

1

2

High-throughput

0.457

High

3634

A0A0S2Z6U5
Uridine phosphorylase

1

2

High-throughput

0.457

High

1307800

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

1226159

CP135
Centrosomal protein of 135 kDa

1

2

High-throughput

0.445

High

167752

PCD17
Protocadherin-17

1

1

Small-scale

0.439

High

399707

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

2

Small-scale

0.437

High

832369

OPRD
Delta-type opioid receptor

1

7

Small-scale

0.437

High

3588

A0A0S2Z639
Uridine phosphorylase 2 isoform 4

1

2

High-throughput

0.417

High

75516

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.417

High

1307751

Q8TAX5
AFF4 protein

1

6

High-throughput

0.417

High

1307770

JSPR1
Junctional sarcoplasmic reticulum protein 1

3

0

High-throughput

0.347

High

1160367

OBF1
POU domain class 2-associating factor 1

2

0

Small-scale

0.341

High

424304

INHA
Inhibin alpha chain

2

0

High-throughput

0.341

High

1307779

TMM43
Transmembrane protein 43

2

0

High-throughput

0.341

High

1178970

EX3L2
Exocyst complex component 3-like protein 2

2

0

High-throughput

0.328

High

846129

CATK
Cathepsin K

2

0

Small-scale

0.323

High

1008042

KCJ10
ATP-sensitive inward rectifier potassium channel 10

1

0

High-throughput

0.299

High

1307743

K319L
Dyslexia-associated protein KIAA0319-like protein

1

0

High-throughput

0.299

High

1307744

EXAS1
Uncharacterized protein EXOC3-AS1

1

0

High-throughput

0.299

High

1307793

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.299

High

1307797

NOL6
Nucleolar protein 6

1

0

High-throughput

0.299

High

1307805

FAME
Factor associated with metabolism and energy

1

0

High-throughput

0.299

High

1307823

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.299

High

1307778

PIMRE
Protein PIMREG

1

0

High-throughput

0.282

High

1012070

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

0

High-throughput

0.279

Low

1307821

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1253262

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025