Protein: ZEB1
Zinc finger E-box-binding homeobox 1 (NIL-2-A zinc finger protein) (Negative regulator of IL2) (Transcription factor 8) (TCF-8)

Gene: ZEB1
Organism: Homo sapiens
Interactions: 185
UniProt ID: P37275

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

790046

CTBP1
C-terminal-binding protein 1

12

10

Small-scale

0.759

High

790001

KLF3
Krueppel-like factor 3

2

20

High-throughput

0.754

High

790000

CTBP2
C-terminal-binding protein 2

6

10

Small-scale

0.729

High

790036

EP300
Histone acetyltransferase p300

4

12

Small-scale

0.692

High

790062

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

3

5

Small-scale

0.678

High

790082

SIR1
NAD-dependent protein deacetylase sirtuin-1

4

5

Small-scale

0.676

High

790023

CDK6
Cyclin-dependent kinase 6

1

0

Small-scale

0.674

High

790081

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

11

Small-scale

0.664

High

790057

DCA15
DDB1- and CUL4-associated factor 15

4

1

Small-scale

0.626

High

339675

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.618

High

790017

CSK21
Casein kinase II subunit alpha

1

8

Small-scale

0.618

High

790058

E4F1
Transcription factor E4F1

1

19

Small-scale

0.618

High

790073

ZN516
Zinc finger protein 516

1

19

Small-scale

0.618

High

790115

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.618

High

250485

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

2

3

Small-scale

0.611

High

790074

HDAC2
Histone deacetylase 2

2

12

High-throughput

0.601

High

163063

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.586

High

413323

P53
Cellular tumor antigen p53

2

7

Small-scale

0.584

High

487027

PARP1
Poly [ADP-ribose] polymerase 1

2

4

Small-scale

0.584

High

790049

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

2

Small-scale

0.584

High

790051

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

177661

SMAD7
Mothers against decapentaplegic homolog 7

1

20

Small-scale

0.561

High

790045

ATM
Serine-protein kinase ATM

1

3

Small-scale

0.561

High

790111

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

2

Small-scale

0.561

High

790035

RBBP4
Histone-binding protein RBBP4

1

6

High-throughput

0.536

High

790047

HDAC1
Histone deacetylase 1

1

12

High-throughput

0.536

High

790063

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

1

Small-scale

0.533

High

790039

TRI26
Tripartite motif-containing protein 26

1

20

Small-scale

0.501

High

790079

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.481

High

124898

GTPB1
GTP-binding protein 1

1

4

Small-scale

0.479

High

138912

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

10

Small-scale

0.479

High

142873

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

187020

PPM1G
Protein phosphatase 1G

1

2

Small-scale

0.479

High

189120

IPO8
Importin-8

1

20

Small-scale

0.479

High

211541

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

4

Small-scale

0.479

High

214724

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

3

Small-scale

0.479

High

219846

SMAD6
Mothers against decapentaplegic homolog 6

1

20

Small-scale

0.479

High

229973

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

Small-scale

0.479

High

246455

KDM1A
Lysine-specific histone demethylase 1A

1

10

Small-scale

0.479

High

317140

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

5

Small-scale

0.479

High

348398

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

Small-scale

0.479

High

424801

ADT2
ADP/ATP translocase 2

1

3

Small-scale

0.479

High

428631

RLA0
Large ribosomal subunit protein uL10

1

3

Small-scale

0.479

High

431004

LA
Lupus La protein

1

4

Small-scale

0.479

High

446717

NPM
Nucleophosmin

1

11

Small-scale

0.479

High

473828

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

504714

FBSP1
F-box/SPRY domain-containing protein 1

1

7

Small-scale

0.479

High

519344

MYB
Transcriptional activator Myb

1

2

High-throughput

0.479

High

534728

BIP
Endoplasmic reticulum chaperone BiP

1

8

Small-scale

0.479

High

536640

HSP7C
Heat shock cognate 71 kDa protein

1

5

Small-scale

0.479

High

549292

SRF
Serum response factor

1

2

High-throughput

0.479

High

550152

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.479

High

552148

ADT3
ADP/ATP translocase 3

1

3

Small-scale

0.479

High

557908

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

559247

XRCC5
X-ray repair cross-complementing protein 5

1

3

Small-scale

0.479

High

562567

RINI
Ribonuclease inhibitor

1

3

Small-scale

0.479

High

581626

MYOD1
Myoblast determination protein 1

1

4

High-throughput

0.479

High

586551

RS2
Small ribosomal subunit protein uS5

1

4

Small-scale

0.479

High

599706

YBOX3
Y-box-binding protein 3

1

13

Small-scale

0.479

High

608477

DDX5
Probable ATP-dependent RNA helicase DDX5

1

3

Small-scale

0.479

High

610553

TCPA
T-complex protein 1 subunit alpha

1

1

Small-scale

0.479

High

612530

RL7
Large ribosomal subunit protein uL30

1

4

Small-scale

0.479

High

620172

NUCL
Nucleolin

1

2

Small-scale

0.479

High

658010

RS3
Small ribosomal subunit protein uS3

1

4

Small-scale

0.479

High

662203

PAX7
Paired box protein Pax-7

1

5

High-throughput

0.479

High

662384

GATA2
Endothelial transcription factor GATA-2

1

5

High-throughput

0.479

High

685117

PAX6
Paired box protein Pax-6

1

5

High-throughput

0.479

High

703102

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

717704

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

Small-scale

0.479

High

761337

HS71L
Heat shock 70 kDa protein 1-like

1

5

Small-scale

0.479

High

761564

HSP74
Heat shock 70 kDa protein 4

1

13

Small-scale

0.479

High

775803

HNF1B
Hepatocyte nuclear factor 1-beta

1

7

High-throughput

0.479

High

784974

RL4
Large ribosomal subunit protein uL4

1

5

Small-scale

0.479

High

789986

RL3
Large ribosomal subunit protein uL3

1

6

Small-scale

0.479

High

789987

RS9
Small ribosomal subunit protein uS4

1

1

Small-scale

0.479

High

789988

YAP1
Transcriptional coactivator YAP1

1

4

Small-scale

0.479

High

789989

SOX2
Transcription factor SOX-2

1

15

High-throughput

0.479

High

789991

CEBPD
CCAAT/enhancer-binding protein delta

1

17

Small-scale

0.479

High

789992

EMD
Emerin

1

2

Small-scale

0.479

High

789994

RL14
Large ribosomal subunit protein eL14

1

4

Small-scale

0.479

High

789995

RT29
Small ribosomal subunit protein mS29

1

2

Small-scale

0.479

High

789996

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

5

Small-scale

0.479

High

789997

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

Small-scale

0.479

High

789998

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

12

Small-scale

0.479

High

789999

NP1L1
Nucleosome assembly protein 1-like 1

1

7

Small-scale

0.479

High

790002

RS3A
Small ribosomal subunit protein eS1

1

2

Small-scale

0.479

High

790005

RS16
Small ribosomal subunit protein uS9

1

7

Small-scale

0.479

High

790006

RS14
Small ribosomal subunit protein uS11

1

2

Small-scale

0.479

High

790008

RS13
Small ribosomal subunit protein uS15

1

2

Small-scale

0.479

High

790009

RL7A
Large ribosomal subunit protein eL8

1

3

Small-scale

0.479

High

790011

RL23A
Large ribosomal subunit protein uL23

1

4

Small-scale

0.479

High

790012

RS6
Small ribosomal subunit protein eS6

1

4

Small-scale

0.479

High

790013

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

790014

YBOX1
Y-box-binding protein 1

1

13

Small-scale

0.479

High

790015

TBA4A
Tubulin alpha-4A chain

1

1

Small-scale

0.479

High

790016

TBB4B
Tubulin beta-4B chain

1

2

Small-scale

0.479

High

790018

RNF4
E3 ubiquitin-protein ligase RNF4

1

18

High-throughput

0.479

High

790019

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

Small-scale

0.479

High

790020

RT35
Small ribosomal subunit protein mS35

1

1

Small-scale

0.479

High

790021

SMAD3
Mothers against decapentaplegic homolog 3

1

20

Small-scale

0.479

High

790024

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

6

Small-scale

0.479

High

790025

EWS
RNA-binding protein EWS

1

4

High-throughput

0.479

High

790026

HEN1
Helix-loop-helix protein 1

1

6

High-throughput

0.479

High

790027

RL6
Large ribosomal subunit protein eL6

1

1

Small-scale

0.479

High

790028

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

790030

HME1
Homeobox protein engrailed-1

1

6

High-throughput

0.479

High

790031

PRDX1
Peroxiredoxin-1

1

2

Small-scale

0.479

High

790034

DHX9
ATP-dependent RNA helicase A

1

5

Small-scale

0.479

High

790037

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

790038

TP53B
TP53-binding protein 1

1

3

High-throughput

0.479

High

790040

ILF2
Interleukin enhancer-binding factor 2

1

5

Small-scale

0.479

High

790041

ILF3
Interleukin enhancer-binding factor 3

1

12

Small-scale

0.479

High

790042

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.479

High

790043

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

790044

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

Small-scale

0.479

High

790048

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

790053

ELF2
ETS-related transcription factor Elf-2

1

4

High-throughput

0.479

High

790054

SMAD2
Mothers against decapentaplegic homolog 2

1

20

Small-scale

0.479

High

790055

SMAD1
Mothers against decapentaplegic homolog 1

1

20

Small-scale

0.479

High

790056

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

14

Small-scale

0.479

High

790059

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

790060

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

10

Small-scale

0.479

High

790064

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

8

Small-scale

0.479

High

790065

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

5

Small-scale

0.479

High

790066

SERB1
SERPINE1 mRNA-binding protein 1

1

1

Small-scale

0.479

High

790067

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

5

Small-scale

0.479

High

790068

TRI58
E3 ubiquitin-protein ligase TRIM58

1

20

Small-scale

0.479

High

790069

DDX1
ATP-dependent RNA helicase DDX1

1

5

Small-scale

0.479

High

790070

H1X
Histone H1.10

1

1

Small-scale

0.479

High

790072

HS105
Heat shock protein 105 kDa

1

15

Small-scale

0.479

High

790075

CBP
CREB-binding protein

1

20

Small-scale

0.479

High

790076

KAT2B
Histone acetyltransferase KAT2B

1

14

Small-scale

0.479

High

790077

DDX17
Probable ATP-dependent RNA helicase DDX17

1

3

Small-scale

0.479

High

790078

CSN5
COP9 signalosome complex subunit 5

1

1

Small-scale

0.479

High

790080

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

5

Small-scale

0.479

High

790083

CHFR
E3 ubiquitin-protein ligase CHFR

1

12

Small-scale

0.479

High

790085

SAHH3
Adenosylhomocysteinase 3

1

1

Small-scale

0.479

High

790087

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

5

Small-scale

0.479

High

790090

MPP8
M-phase phosphoprotein 8

1

5

Small-scale

0.479

High

790091

FEV
Protein FEV

1

5

High-throughput

0.479

High

790092

GNL3
Guanine nucleotide-binding protein-like 3

1

3

Small-scale

0.479

High

790093

UBP26
Ubiquitin carboxyl-terminal hydrolase 26

1

10

Small-scale

0.479

High

790094

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

20

Small-scale

0.479

High

790095

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

5

Small-scale

0.479

High

790096

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

2

Small-scale

0.479

High

790097

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

6

Small-scale

0.479

High

790098

DDX21
Nucleolar RNA helicase 2

1

8

Small-scale

0.479

High

790102

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

1

Small-scale

0.479

High

790103

UBP35
Ubiquitin carboxyl-terminal hydrolase 35

1

13

Small-scale

0.479

High

790104

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

790106

NUP50
Nuclear pore complex protein Nup50

1

1

High-throughput

0.479

High

790107

ZMIZ1
Zinc finger MIZ domain-containing protein 1

1

1

Small-scale

0.479

High

790108

UBP18
Ubl carboxyl-terminal hydrolase 18

1

11

Small-scale

0.479

High

790109

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

Small-scale

0.479

High

790110

LHX6
LIM/homeobox protein Lhx6

1

8

High-throughput

0.479

High

790112

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

10

Small-scale

0.479

High

790113

RTRAF
RNA transcription, translation and transport factor protein

1

1

Small-scale

0.479

High

790050

NC2A
Dr1-associated corepressor

1

0

Small-scale

0.460

High

428075

RLA1
Large ribosomal subunit protein P1

1

0

Small-scale

0.458

High

583827

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

Small-scale

0.458

High

697447

PYR1
Multifunctional protein CAD

1

0

Small-scale

0.458

High

790003

RS8
Small ribosomal subunit protein eS8

1

0

Small-scale

0.458

High

790004

RS15A
Small ribosomal subunit protein uS8

1

0

Small-scale

0.458

High

790007

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.458

High

790010

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

Small-scale

0.458

High

790032

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.458

High

790052

ELOB
Elongin-B

1

0

High-throughput

0.458

High

790084

PTCD3
Small ribosomal subunit protein mS39

1

0

Small-scale

0.458

High

790086

VCIP1
Deubiquitinating protein VCPIP1

1

0

Small-scale

0.458

High

790088

INT15
Integrator complex subunit 15

1

0

Small-scale

0.458

High

790089

INT14
Integrator complex subunit 14

1

0

Small-scale

0.458

High

790099

INT13
Integrator complex subunit 13

1

0

Small-scale

0.458

High

790100

INT10
Integrator complex subunit 10

1

0

Small-scale

0.458

High

790101

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

790114

RTCB
RNA-splicing ligase RtcB homolog

1

0

Small-scale

0.458

High

555918

CADH1
Cadherin-1

1

3

Small-scale

0.437

High

789985

HSPA9
Stress-70 protein, mitochondrial

1

10

Small-scale

0.437

High

789990

EFTU
Elongation factor Tu, mitochondrial

1

3

Small-scale

0.437

High

789993

SERPH
Serpin H1

1

3

Small-scale

0.437

High

790022

S25A3
Solute carrier family 25 member 3

1

4

Small-scale

0.437

High

790029

EF1A2
Elongation factor 1-alpha 2

1

1

Small-scale

0.437

High

790033

CKAP4
Cytoskeleton-associated protein 4

1

9

Small-scale

0.437

High

790061

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

1

Small-scale

0.437

High

790105

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

3

Small-scale

0.437

High

790071

RT27
Small ribosomal subunit protein mS27

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025