HitPredict

Interactor 1: AP1G1 (O43747)
AP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1)
Gene: AP1G1

Interactor 2: CLH1 (Q00610)
Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
Gene: CLTC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.829

Property	Details
Experiments	21411634, 11387476, 17052248
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Alpha_adaptinC2~Clathrin
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0016020 - membrane GO:0030136 - clathrin-coated vesicle GO:0032588 - trans-Golgi network membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 822 Hs			1 1675
+	Hs
		321529 AP2A1_HUMAN (3-808): 0: 594: 24.39		CLH1_HUMAN (1-1675): 0: 3132: 100.00
+	Mm
		567504 AP2A1_MOUSE (3-808): 0: 595: 25.00		CLH1_MOUSE (1-1675): 0: 3131: 99.88
+	Hs
		302138 AP2A2_HUMAN (3-813): 0: 582: 24.55		CLH1_HUMAN (1-1675): 0: 3132: 100.00
+	Hs
		925852 AP2B1_HUMAN (30-800): 0: 552: 16.59		CLH1_HUMAN (1-1675): 0: 3132: 100.00
+	Hs
		960765 AP1B1_HUMAN (30-800): 0: 547: 17.36		CLH1_HUMAN (1-1675): 0: 3132: 100.00
+	Rn
		509763 AP2B1_RAT (30-800): 0: 552: 16.59		CLH1_RAT (1-1675): 0: 3123: 99.76
+	Hs
		150206 AP3D1_HUMAN (7-712): 6.12e-177: 542: 21.24		CLH1_HUMAN (1-1675): 0: 3132: 100.00
+	At
		1012804 APBLB_ARATH (30-812): 0: 548: 16.77		CLAH1_ARATH (6-1636): 0: 2638: 56.38
+	Sc
		604486 AP1G1_YEAST (5-806): 0: 548: 30.83		CLH_YEAST (5-1648): 0: 2443: 49.79