HitPredict

Interactor 1: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP

Interactor 2: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	26344096, 34795264
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 147
+	Hs
		214152 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		214336 SPOP_HUMAN (1-374): 1.97e-125: 367: 100.00		UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43
+	Hs
		307160 KLHL2_HUMAN (146-373): 5.74e-62: 210: 21.05		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		895941 KLHL3_HUMAN (152-371): 2.59e-59: 203: 22.73		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		849470 KLHL9_HUMAN (158-368): 3.82e-57: 198: 19.73		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		849329 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		828997 KEAP1_HUMAN (132-372): 2.99e-56: 196: 19.92		UBE2A_HUMAN (2-144): 1.41e-70: 210: 39.16