Interactor 1: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP
Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.97 | 1.00 | 0.986 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25278611, 22632832, 28216678, 29160310, 31559706, 30244836, 36604567, 21577200, 16524876, 33961781, 34510437, 19261606, 22013077, 22911784, 19256485, 21988832, 25011449 |
| Identification Methods | affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, two hybrid, isothermal titration calorimetry, molecular sieving, anti tag coimmunoprecipitation |
| Interaction Type | physical association, association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | BTB~Cullin |
| Common GO terms | GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0031463 - Cul3-RING ubiquitin ligase complex and 2 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
