HitPredict

Interactor 1: MYO1B (O43795)
Unconventional myosin-Ib (MYH-1c) (Myosin I alpha) (MMI-alpha) (MMIa)
Gene: MYO1B

Interactor 2: PK3CA (P42336)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: PIK3CA

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	27684187, 34591642
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1136 Hs			1 1068
+	Hs
		787337 MYO5A_HUMAN (2-1125): 0: 1013: 28.64		PK3CA_HUMAN (1-1068): 0: 1325: 100.00
+	Hs
		297317 MYO1D_HUMAN (16-794): 0: 706: 47.73		PK3CA_HUMAN (1-1068): 0: 1325: 100.00
+	Hs
		117624 MYO1C_HUMAN (778-1136): 9.49e-71: 259: 25.95		PK3CA_HUMAN (1-1068): 0: 1325: 100.00
+	Hs
		724697 MYH9_HUMAN (694-1133): 5.37e-12: 72.7: 7.63		PK3CA_HUMAN (1-1068): 0: 1325: 100.00
+	Hs
		725105 MYH10_HUMAN (771-1132): 7.68e-10: 65.8: 7.47		PK3CA_HUMAN (1-1068): 0: 1325: 100.00
+	Hs
		128818 MYH9_HUMAN (694-1133): 5.37e-12: 72.7: 7.63		P3C2A_HUMAN (300-1064): 0: 727: 31.92
+	Hs
		724921 MYH9_HUMAN (694-1133): 5.37e-12: 72.7: 7.63		PK3C3_HUMAN (348-646): 4.24e-71: 257: 23.01