HitPredict

Interactor 1: TYOBP (O43914)
TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein)
Gene: TYROBP

Interactor 2: NCTR2 (O95944)
Natural cytotoxicity triggering receptor 2 (Lymphocyte antigen 95 homolog) (NK cell-activating receptor) (Natural killer cell p44-related protein) (NK-p44) (NKp44) (CD antigen CD336)
Gene: NCR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	10049942, 14707061
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006968 - cellular defense response GO:0007165 - signal transduction GO:0009986 - cell surface
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 113 Hs			1 276
+	Hs
		217311 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		CLM6_HUMAN (2-177): 3.56e-47: 158: 27.84
+	Mm
		222481 TYOBP_MOUSE (1-113): 8.4e-64: 190: 73.04		CLM4_MOUSE (4-208): 5.98e-49: 163: 22.60
+	Hs
		217362 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		TREM1_HUMAN (1-219): 5.57e-45: 153: 26.47
+	Hs
		66493 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		CLM7_HUMAN (18-146): 1.71e-42: 146: 25.58
+	Hs
		3044 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		CD3CH_HUMAN (2-160): 9.03e-42: 144: 24.85
+	Hs
		217328 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		CLM5_HUMAN (22-165): 4.31e-39: 136: 22.92
+	Hs
		217366 TYOBP_HUMAN (1-113): 8.75e-66: 195: 100.00		TREM2_HUMAN (8-162): 1.96e-36: 131: 22.09
+	Mm
		222482 TYOBP_MOUSE (1-113): 8.4e-64: 190: 73.04		Q8BNV8_MOUSE (1-225): 1.3e-38: 136: 26.25
+	Mm
		222485 TYOBP_MOUSE (1-113): 8.4e-64: 190: 73.04		TREM3_MOUSE (15-141): 5.91e-31: 115: 23.08