Protein: AK1C2
Aldo-keto reductase family 1 member C2 (EC 1.-.-.-) (EC 1.1.1.112) (EC 1.1.1.209) (EC 1.1.1.53) (EC 1.1.1.62) (EC 1.3.1.20) (3-alpha-HSD3) (Chlordecone reductase homolog HAKRD) (Dihydrodiol dehydrogenase 2) (DD-2) (DD2) (Dihydrodiol dehydrogenase/bile acid-binding protein) (DD/BABP) (Type III 3-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.357)

Gene: AK1C2, AKR1C2
Organism: Homo sapiens
Interactions: 40
UniProt ID: P52895

Gene Ontology (top 5):
GO:0004032 - aldose reductase (NADPH) activity
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005829 - cytosol
GO:0006693 - prostaglandin metabolic process
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

838904

AK1C3
Aldo-keto reductase family 1 member C3

6

11

High-throughput

0.943

High

605036

AK1C4
Aldo-keto reductase family 1 member C4

5

11

High-throughput

0.919

High

915021

AK1C1
Aldo-keto reductase family 1 member C1

5

11

High-throughput

0.919

High

189132

IPO8
Importin-8

2

1

High-throughput

0.611

High

915024

ZFP1
Zinc finger protein 1 homolog

3

1

High-throughput

0.609

High

915017

AK1C2
Aldo-keto reductase family 1 member C2

1

11

Small-scale

0.575

High

187321

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

3

High-throughput

0.536

High

602766

AATC
Aspartate aminotransferase, cytoplasmic

1

6

High-throughput

0.536

High

915029

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.536

High

259668

BRD4
Bromodomain-containing protein 4

2

3

High-throughput

0.521

High

219145

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.518

High

733314

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.489

High

915030

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.489

High

915035

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

2

High-throughput

0.489

High

135904

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

2

High-throughput

0.479

High

400522

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

425394

ISG15
Ubiquitin-like protein ISG15

1

3

High-throughput

0.479

High

915018

TERA
Transitional endoplasmic reticulum ATPase

1

9

High-throughput

0.479

High

915020

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

915022

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.479

High

915026

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.479

High

915034

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

353135

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.470

High

487120

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

791204

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

125341

LEG9
Galectin-9

1

1

High-throughput

0.445

High

915019

VIGLN
Vigilin

1

1

High-throughput

0.437

High

915032

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.426

High

915036

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.426

High

261138

NSMA
Sphingomyelin phosphodiesterase 2

1

3

High-throughput

0.407

High

604998

HXB6
Homeobox protein Hox-B6

1

2

High-throughput

0.407

High

915031

TMM59
Transmembrane protein 59

1

2

High-throughput

0.407

High

915033

CLIP2
CAP-Gly domain-containing linker protein 2

1

1

High-throughput

0.407

High

915027

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.279

Low

583232

FOLR1
Folate receptor alpha

1

0

High-throughput

0.249

Low

868989

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.249

Low

915023

THOC5
THO complex subunit 5

1

0

High-throughput

0.232

Low

915025

THOC1
THO complex subunit 1

1

0

High-throughput

0.232

Low

915028

KIFC1
Kinesin-like protein KIFC1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025