Protein: AK1C3
Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239, EC 1.1.1.64)

Gene: AK1C3, AKR1C3
Organism: Homo sapiens
Interactions: 28
UniProt ID: P42330

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0001758 - retinal dehydrogenase (NAD+) activity
GO:0004032 - aldose reductase (NADPH) activity
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

838904

AK1C2
Aldo-keto reductase family 1 member C2

6

11

High-throughput

0.943

High

838908

AK1C1
Aldo-keto reductase family 1 member C1

5

11

High-throughput

0.922

High

605035

AK1C4
Aldo-keto reductase family 1 member C4

3

11

High-throughput

0.861

High

838903

AK1D1
Aldo-keto reductase family 1 member D1

3

11

High-throughput

0.861

High

238658

AK1BA
Aldo-keto reductase family 1 member B10

1

12

High-throughput

0.618

High

400432

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

4

High-throughput

0.584

High

211546

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

1

Small-scale

0.561

High

838901

MAGAB
Melanoma-associated antigen 11

1

1

High-throughput

0.541

High

838905

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

1

High-throughput

0.541

High

838913

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

1

High-throughput

0.541

High

838914

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.536

High

353068

AGR2
Anterior gradient protein 2 homolog

2

3

Small-scale

0.533

High

838920

ZHX1
Zinc fingers and homeoboxes protein 1

1

0

High-throughput

0.518

High

838909

HABP4
Intracellular hyaluronan-binding protein 4

1

0

High-throughput

0.513

High

259575

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

425360

ISG15
Ubiquitin-like protein ISG15

1

3

High-throughput

0.479

High

521237

ARAF
Serine/threonine-protein kinase A-Raf

1

4

High-throughput

0.479

High

838902

CDK9
Cyclin-dependent kinase 9

1

3

High-throughput

0.479

High

838906

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.479

High

838912

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

838918

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

838907

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

838916

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

838911

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

838919

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

0

High-throughput

0.438

High

838915

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.407

High

838917

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.279

Low

838910

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025