HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: MSH6 (P52701)
DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160)
Gene: MSH6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20085707
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 545 Hs			1 1360
+	Mm
		869803 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		MSH6_MOUSE (1-1360): 0: 1442: 85.34
+	Hs
		855535 UHRF1_HUMAN (268-410): 2.94e-28: 121: 23.87		MSH6_HUMAN (1-1360): 0: 1486: 100.00
+	Hs
		855463 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		MSH6_HUMAN (1-1360): 0: 1486: 100.00
+	Hs
		855581 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		MSH6_HUMAN (1-1360): 0: 1486: 100.00
+	Hs
		217456 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		MSH2_HUMAN (393-1360): 0: 824: 21.88
+	Mm
		794356 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		MSH2_MOUSE (393-1360): 0: 818: 21.13
+	Hs
		594207 UHRF2_HUMAN (287-410): 6.73e-27: 117: 24.22		MSH3_HUMAN (173-1357): 0: 835: 22.16
+	Hs
		794301 UHRF1_HUMAN (268-410): 2.94e-28: 121: 23.87		MSH2_HUMAN (393-1360): 0: 824: 21.88
+	Hs
		794339 TRI33_HUMAN (336-540): 1.26e-16: 85.6: 16.13		MSH2_HUMAN (393-1360): 0: 824: 21.88
+	Hs
		331813 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44
+	Hs
		1017344 BPTF_HUMAN (273-363): 9.66e-19: 92.5: 28.57		NSD3_HUMAN (4-390): 2.84e-86: 311: 19.51
+	Hs
		331678 NSD2_HUMAN (30-345): 3.09e-17: 87.5: 14.80		NSD2_HUMAN (4-411): 1.45e-80: 293: 17.44