Protein: PTN21
Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1)

Gene: PTN21, PTPN21
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q16825

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005737 - cytoplasm
GO:0005856 - cytoskeleton
GO:0006470 - protein dephosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1163770

RASD1
Dexamethasone-induced Ras-related protein 1

2

15

High-throughput

0.783

High

908204

BMX
Cytoplasmic tyrosine-protein kinase BMX

3

20

Small-scale

0.780

High

1163719

PTN21
Tyrosine-protein phosphatase non-receptor type 21

2

18

High-throughput

0.757

High

557330

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.754

High

966369

1433G
14-3-3 protein gamma

3

20

High-throughput

0.662

High

1151519

TRIP6
Thyroid receptor-interacting protein 6

3

18

High-throughput

0.656

High

1163737

KIBRA
Protein KIBRA

3

20

High-throughput

0.650

High

1145738

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

Small-scale

0.648

High

230534

KIF1C
Kinesin-like protein KIF1C

2

17

Small-scale

0.643

High

1163758

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

3

13

Small-scale

0.640

High

862185

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.624

High

1163725

WWC2
Protein WWC2

2

20

High-throughput

0.611

High

1163757

PAR6B
Partitioning defective 6 homolog beta

3

14

High-throughput

0.609

High

347733

BAG3
BAG family molecular chaperone regulator 3

2

3

High-throughput

0.606

High

1121239

TRI14
Tripartite motif-containing protein 14

2

9

High-throughput

0.606

High

1163732

MOB3C
MOB kinase activator 3C

2

11

High-throughput

0.606

High

1163744

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

20

High-throughput

0.606

High

1163749

FBX17
F-box only protein 17

2

10

High-throughput

0.606

High

1163762

NEK6
Serine/threonine-protein kinase Nek6

2

14

High-throughput

0.606

High

1163767

PAK5
Serine/threonine-protein kinase PAK 5

2

13

High-throughput

0.606

High

1163740

RHPN1
Rhophilin-1

3

15

High-throughput

0.604

High

729872

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.601

High

611894

RL35A
Large ribosomal subunit protein eL33

2

2

High-throughput

0.584

High

1163736

ARMC8
Armadillo repeat-containing protein 8

2

2

High-throughput

0.584

High

1163759

WDR26
WD repeat-containing protein 26

2

17

High-throughput

0.584

High

868179

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.580

High

1163729

NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor

2

0

High-throughput

0.580

High

1163752

AJUBA
LIM domain-containing protein ajuba

2

18

High-throughput

0.574

High

1163747

LPP
Lipoma-preferred partner

2

19

High-throughput

0.558

High

1063286

GOGA2
Golgin subfamily A member 2

2

10

High-throughput

0.553

High

1163739

CTSR1
Cation channel sperm-associated protein 1

2

20

High-throughput

0.553

High

1163748

MGN2
Protein mago nashi homolog 2

2

1

High-throughput

0.553

High

1163755

SNX18
Sorting nexin-18

2

2

High-throughput

0.553

High

1163763

CWC22
Pre-mRNA-splicing factor CWC22 homolog

2

7

High-throughput

0.553

High

1163764

PAR6A
Partitioning defective 6 homolog alpha

2

20

High-throughput

0.553

High

963298

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.536

High

971577

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.536

High

990276

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

1049331

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1163746

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

11

High-throughput

0.536

High

625416

CSK22
Casein kinase II subunit alpha'

2

11

High-throughput

0.533

High

997750

CSK21
Casein kinase II subunit alpha

2

13

High-throughput

0.533

High

182131

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.513

High

1163765

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.513

High

1163745

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

217268

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

1

High-throughput

0.479

High

230033

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

8

High-throughput

0.479

High

272223

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.479

High

549169

CDK4
Cyclin-dependent kinase 4

1

8

High-throughput

0.479

High

810131

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

859303

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.479

High

859846

RL28
Large ribosomal subunit protein eL28

1

3

High-throughput

0.479

High

1016030

RL19
Large ribosomal subunit protein eL19

1

2

High-throughput

0.479

High

1163720

DUS7
Dual specificity protein phosphatase 7

1

8

High-throughput

0.479

High

1163723

AMOT
Angiomotin

1

20

High-throughput

0.479

High

1163724

DCAF8
DDB1- and CUL4-associated factor 8

1

12

High-throughput

0.479

High

1163726

ELP2
Elongator complex protein 2

1

2

High-throughput

0.479

High

1163728

RBP10
Ran-binding protein 10

1

9

High-throughput

0.479

High

1163735

MAEA
E3 ubiquitin-protein transferase MAEA

1

11

High-throughput

0.479

High

1163743

NEK7
Serine/threonine-protein kinase Nek7

1

17

High-throughput

0.479

High

1163751

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

3

High-throughput

0.479

High

1163754

DCAF5
DDB1- and CUL4-associated factor 5

1

14

High-throughput

0.479

High

1163756

RANB9
Ran-binding protein 9

1

9

High-throughput

0.479

High

1163760

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

8

High-throughput

0.479

High

1163766

GID8
Glucose-induced degradation protein 8 homolog

1

11

High-throughput

0.479

High

1163722

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

180299

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.458

High

229021

AKAP8
A-kinase anchor protein 8

1

0

High-throughput

0.458

High

1163772

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.458

High

691050

1433T
14-3-3 protein theta

1

20

High-throughput

0.445

High

1163721

INAVA
Innate immunity activator protein

1

1

High-throughput

0.445

High

301073

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.437

High

334787

IPO7
Importin-7

1

15

High-throughput

0.437

High

964986

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.437

High

1163727

CEP85
Centrosomal protein of 85 kDa

1

20

High-throughput

0.437

High

1163731

STXB4
Syntaxin-binding protein 4

1

20

High-throughput

0.437

High

1163741

DDX54
ATP-dependent RNA helicase DDX54

1

7

High-throughput

0.437

High

1163742

BPIB1
BPI fold-containing family B member 1

1

3

High-throughput

0.437

High

1163750

SAHH3
Adenosylhomocysteinase 3

1

8

High-throughput

0.437

High

1163753

TMX3
Protein disulfide-isomerase TMX3

1

13

High-throughput

0.437

High

1163768

DJB11
DnaJ homolog subfamily B member 11

1

3

High-throughput

0.437

High

1163769

ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

552970

PIP
Prolactin-inducible protein

1

1

High-throughput

0.407

High

1163733

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

9

High-throughput

0.407

High

171073

VP26C
Vacuolar protein sorting-associated protein 26C

2

0

High-throughput

0.316

High

1163730

ZN497
Zinc finger protein 497

2

0

High-throughput

0.316

High

1163734

ATOSB
Atos homolog protein B

2

0

High-throughput

0.316

High

48143

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.249

Low

943214

NRG3
Pro-neuregulin-3, membrane-bound isoform

1

0

Small-scale

0.249

Low

1163457

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.249

Low

1163738

P20D2
Xaa-Arg dipeptidase

1

0

High-throughput

0.249

Low

1163761

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

0

High-throughput

0.249

Low

1163771

IFT52
Intraflagellar transport protein 52 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025