HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20085707
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 545 Hs			1 164
+	Hs
		217471 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		217429 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Mm
		1161053 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		SRSF1_MOUSE (9-80): 1.1e-25: 100: 48.65
+	Mm
		952212 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		SRSF3_MOUSE (1-164): 6.39e-27: 100: 100.00
+	Mm
		665773 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		PABP1_MOUSE (1-91): 1.3e-20: 89.2: 25.77
+	Hs
		1059643 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35
+	Hs
		951965 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00
+	Hs
		992774 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		1028656 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34
+	Hs
		703377 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		CSTF2_HUMAN (10-110): 1.87e-25: 103: 25.47
+	Hs
		1031332 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09
+	Hs
		516522 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		951935 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00
+	Hs
		992741 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		1018454 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34
+	Hs
		1028548 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79
+	Hs
		516483 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		1028915 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44
+	Hs
		1303041 UHRF1_HUMAN (268-410): 2.94e-28: 121: 23.87		RBM4_HUMAN (11-88): 3.45e-18: 81.9: 28.21
+	Hs
		1018455 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44