HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20185822
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 545 Hs			1 482
+	Hs
		217495 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		299055 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		299073 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		1038610 PF21A_HUMAN (130-352): 7.15e-33: 135: 23.38		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1270364 PF21A_HUMAN (130-352): 7.15e-33: 135: 23.38		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Mm
		56897 CHD5_MOUSE (92-496): 2.13e-30: 128: 14.91		HDAC1_MOUSE (1-482): 0: 672: 99.38
+	Hs
		1038382 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1059770 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Mm
		56900 CHD5_MOUSE (92-496): 2.13e-30: 128: 14.91		HDAC2_MOUSE (1-478): 0: 664: 85.71
+	Hs
		1038563 CHD5_HUMAN (288-504): 6.06e-28: 121: 17.41		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1038653 UHRF1_HUMAN (268-410): 2.94e-28: 121: 23.87		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1255037 CHD5_HUMAN (288-504): 6.06e-28: 121: 17.41		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		1018465 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1038637 UHRF2_HUMAN (287-410): 6.73e-27: 117: 24.22		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1018617 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		1017292 BPTF_HUMAN (273-363): 9.66e-19: 92.5: 28.57		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Dm
		332806 CHDM_DROME (34-487): 2.06e-20: 97.9: 11.66		HDAC1_DROME (6-477): 0: 658: 77.33
+	Sc
		693063 RCO1_YEAST (143-476): 9.27e-35: 140: 14.89		RPD3_YEAST (8-421): 0: 580: 61.48
+	Sp
		223490 YAC5_SCHPO (235-529): 1.56e-41: 155: 22.33		CLR6_SCHPO (8-405): 0: 563: 62.10
+	Ce
		184848 CHD3_CAEEL (347-513): 4.42e-21: 99.9: 15.34		HDA1_CAEEL (3-455): 0: 605: 63.60