HitPredict

Interactor 1: AIRE (O43918)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)
Gene: AIRE

Interactor 2: H2A1C (Q93077)
Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l)
Gene: H2AC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20085707
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 545 Hs			1 130
+	Hs
		217435 AIRE_HUMAN (1-545): 1.25e-134: 403: 100.00		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Mm
		83337 AIRE_MOUSE (16-544): 2.93e-123: 374: 71.72		H2A1B_MOUSE (1-130): 1.52e-67: 201: 98.46
+	Hs
		299066 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2A2A_HUMAN (1-130): 9.4e-68: 202: 98.46
+	Hs
		299027 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2A1B_HUMAN (1-130): 1.52e-67: 201: 98.46
+	Hs
		299030 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Hs
		299035 PHF14_HUMAN (126-484): 3.61e-44: 169: 16.71		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Hs
		391704 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2A1B_HUMAN (1-130): 1.52e-67: 201: 98.46
+	Hs
		470387 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Hs
		1059795 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2A1H_HUMAN (1-128): 7.48e-67: 199: 98.44
+	Hs
		555582 PF21A_HUMAN (130-352): 7.15e-33: 135: 23.38		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Hs
		1059717 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2A2B_HUMAN (1-130): 3.14e-66: 198: 95.39
+	Hs
		1059647 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2A2C_HUMAN (1-130): 5.75e-65: 194: 96.92
+	Sc
		392566 RCO1_YEAST (143-476): 9.27e-35: 140: 14.89		H2A2_YEAST (16-128): 3.45e-59: 180: 81.42
+	Hs
		555466 CHD4_HUMAN (74-489): 2.06e-30: 128: 13.43		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Hs
		391675 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		H2A1B_HUMAN (1-130): 1.52e-67: 201: 98.46
+	Hs
		1018640 CHD3_HUMAN (74-503): 9.23e-27: 117: 14.16		H2A1H_HUMAN (1-128): 7.48e-67: 199: 98.44
+	Hs
		555610 UHRF1_HUMAN (268-410): 2.94e-28: 121: 23.87		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Hs
		331703 NSD2_HUMAN (30-345): 3.09e-17: 87.5: 14.80		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Hs
		555434 BPTF_HUMAN (273-363): 9.66e-19: 92.5: 28.57		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Dm
		332757 CHDM_DROME (34-487): 2.06e-20: 97.9: 11.66		H2A_DROME (17-125): 1.09e-59: 181: 90.83