HitPredict

Interactor 1: NHR49 (O45666)
Nuclear hormone receptor family member nhr-49
Gene: nhr-49

Interactor 2: NHR20 (Q09565)
Nuclear hormone receptor family member nhr-20
Gene: nhr-20

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.815

Property	Details
Experiments	19123269, 23791784
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Ce			1 457
+	Ce
		220334 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q20097_CAEEL (18-456): 3.53e-91: 284: 21.97
+	Ce
		220328 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR22_CAEEL (2-457): 3.02e-88: 281: 22.22
+	Ce
		220345 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR80_CAEEL (2-457): 1.4e-84: 270: 22.17
+	Ce
		184317 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O17020_CAEEL (39-443): 7.38e-86: 268: 23.89
+	Ce
		220333 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q19438_CAEEL (17-441): 1.38e-85: 268: 24.41
+	Ce
		220342 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR76_CAEEL (17-454): 4.58e-84: 268: 20.98
+	Ce
		184860 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH169_CAEEL (19-441): 4.77e-85: 266: 25.88
+	Ce
		220319 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR49_CAEEL (17-455): 1e-81: 263: 22.82
+	Ce
		220087 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O45507_CAEEL (17-441): 2.71e-83: 262: 25.87
+	Ce
		106951 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH114_CAEEL (6-455): 5.76e-80: 255: 19.33
+	Ce
		220326 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR19_CAEEL (3-455): 6.68e-78: 252: 18.04
+	Ce
		220340 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR11_CAEEL (18-457): 3.72e-78: 252: 20.65
+	Ce
		219559 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O44577_CAEEL (18-457): 3.58e-78: 251: 23.65
+	Ce
		184020 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O16538_CAEEL (19-440): 2.81e-79: 250: 21.28
+	Ce
		108377 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		G5EGP2_CAEEL (12-441): 1.16e-78: 249: 21.48
+	Ce
		185183 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR79_CAEEL (18-457): 2.7e-75: 244: 25.05
+	Ce
		220347 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q95Y05_CAEEL (2-455): 6.76e-72: 234: 19.38
+	Ce
		184366 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O17081_CAEEL (16-93): 7.45e-14: 74.7: 41.03
+	Ce
		220343 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q86PI8_CAEEL (14-146): 4.77e-14: 74.7: 32.12
+	Ce
		184019 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		O16537_CAEEL (184-425): 1.25e-13: 73.6: 24.69