Protein: ACVL1
Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)

Gene: ACVL1, Acvrl1
Organism: Mus musculus
Interactions: 90
UniProt ID: Q61288

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001666 - response to hypoxia
GO:0001701 - in utero embryonic development
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0001938 - positive regulation of endothelial cell proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1142456

TGFR1
TGF-beta receptor type-1

3

19

Small-scale

0.827

High

49696

MELT
Ventricular zone-expressed PH domain-containing protein 1

1

1

High-throughput

0.618

High

103569

G5E884
non-specific serine/threonine protein kinase

1

5

High-throughput

0.618

High

250433

AURKB
Aurora kinase B

1

3

High-throughput

0.618

High

291462

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

8

High-throughput

0.618

High

728819

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

4

High-throughput

0.618

High

1102094

GSK3A
Glycogen synthase kinase-3 alpha

1

10

High-throughput

0.618

High

1141067

KIF1B
Kinesin-like protein KIF1B

1

1

High-throughput

0.618

High

1142453

TGFR2
TGF-beta receptor type-2

1

19

Small-scale

0.618

High

1142457

OXSR1
Serine/threonine-protein kinase OSR1

1

11

High-throughput

0.618

High

1142459

RASL2
Ras GTPase-activating protein 4

1

3

High-throughput

0.618

High

1142473

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

7

High-throughput

0.618

High

1142477

Q91XL1
Leucine-rich HEV glycoprotein

1

20

Small-scale

0.618

High

1142478

NEK8
Serine/threonine-protein kinase Nek8

1

4

High-throughput

0.618

High

1142486

GRAP
GRB2-related adapter protein

1

17

High-throughput

0.618

High

1142496

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

1

High-throughput

0.618

High

1142500

KC1E
Casein kinase I isoform epsilon

1

3

High-throughput

0.618

High

1142503

E2AK4
eIF-2-alpha kinase GCN2

1

2

High-throughput

0.618

High

1142505

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

11

High-throughput

0.618

High

1142506

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.618

High

1142510

GSK3B
Glycogen synthase kinase-3 beta

1

9

High-throughput

0.618

High

1142454

EGLN
Endoglin

2

12

Small-scale

0.584

High

1142471

ARHG6
Rho guanine nucleotide exchange factor 6

1

5

High-throughput

0.553

High

1142481

Q99K94
Signal transducer and activator of transcription

1

2

High-throughput

0.553

High

1142498

PKHO1
Pleckstrin homology domain-containing family O member 1

1

1

High-throughput

0.553

High

1142502

PKHB1
Pleckstrin homology domain-containing family B member 1

1

1

High-throughput

0.553

High

101839

F8WJD6
Mex3 RNA binding family member B

1

2

High-throughput

0.479

High

520210

RAPSN
43 kDa receptor-associated protein of the synapse

1

3

High-throughput

0.479

High

877531

CADH5
Cadherin-5

1

9

Small-scale

0.479

High

906270

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

7

High-throughput

0.479

High

906651

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

7

High-throughput

0.479

High

915327

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

6

High-throughput

0.479

High

926279

RHES
GTP-binding protein Rhes

1

4

High-throughput

0.479

High

930633

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

6

High-throughput

0.479

High

983316

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

997513

RASLC
Ras-like protein family member 12

1

5

High-throughput

0.479

High

1112466

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

2

High-throughput

0.479

High

1141493

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

7

High-throughput

0.479

High

1142039

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

1

3

High-throughput

0.479

High

1142149

FZD7
Frizzled-7

1

2

High-throughput

0.479

High

1142455

AR13B
ADP-ribosylation factor-like protein 13B

1

3

High-throughput

0.479

High

1142458

BCR
Breakpoint cluster region protein

1

2

High-throughput

0.479

High

1142463

RAP2A
Ras-related protein Rap-2a

1

5

High-throughput

0.479

High

1142464

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

2

High-throughput

0.479

High

1142468

PEX5R
PEX5-related protein

1

1

High-throughput

0.479

High

1142472

RAB38
Ras-related protein Rab-38

1

3

High-throughput

0.479

High

1142475

WDR13
WD repeat-containing protein 13

1

2

High-throughput

0.479

High

1142476

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

1142482

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

14

High-throughput

0.479

High

1142483

ARL4D
ADP-ribosylation factor-like protein 4D

1

5

High-throughput

0.479

High

1142484

PKP2
Plakophilin-2

1

7

High-throughput

0.479

High

1142485

ARHGP
Rho guanine nucleotide exchange factor 25

1

1

High-throughput

0.479

High

1142488

ELP3
Elongator complex protein 3

1

1

High-throughput

0.479

High

1142489

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1142491

REBL1
GTPase RhebL1

1

5

High-throughput

0.479

High

1142492

DCAF6
DDB1- and CUL4-associated factor 6

1

4

High-throughput

0.479

High

1142495

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1142499

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

16

High-throughput

0.479

High

1142504

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

9

High-throughput

0.479

High

1142508

SEC12
Guanine nucleotide-exchange factor SEC12

1

3

High-throughput

0.479

High

1142511

PAR6A
Partitioning defective 6 homolog alpha

1

7

High-throughput

0.479

High

854553

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

0

High-throughput

0.458

High

919014

RAB3C
Ras-related protein Rab-3C

1

0

High-throughput

0.458

High

936455

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.458

High

1142501

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.458

High

1142509

MPP2
MAGUK p55 subfamily member 2

1

0

High-throughput

0.458

High

739458

PPM1B
Protein phosphatase 1B

1

1

High-throughput

0.437

High

872238

RD23A
UV excision repair protein RAD23 homolog A

1

3

High-throughput

0.437

High

899109

RAB6B
Ras-related protein Rab-6B

1

10

High-throughput

0.437

High

901297

NAA20
N-alpha-acetyltransferase 20

1

2

High-throughput

0.437

High

1111898

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

8

High-throughput

0.437

High

1142452

RANT
GTP-binding nuclear protein Ran, testis-specific isoform

1

3

High-throughput

0.437

High

1142460

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.437

High

1142462

TTC28
Tetratricopeptide repeat protein 28

1

4

High-throughput

0.437

High

1142466

CDC23
Cell division cycle protein 23 homolog

1

3

High-throughput

0.437

High

1142469

KBRS1
NF-kappa-B inhibitor-interacting Ras-like protein 1

1

10

High-throughput

0.437

High

1142470

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

12

High-throughput

0.437

High

1142474

DUS18
Dual specificity protein phosphatase 18

1

3

High-throughput

0.437

High

1142480

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

4

High-throughput

0.437

High

1142487

KLH35
Kelch-like protein 35

1

2

High-throughput

0.437

High

1142490

DUS26
Dual specificity protein phosphatase 26

1

3

High-throughput

0.437

High

1142493

FBX3
F-box only protein 3

1

2

High-throughput

0.437

High

1142494

FXL12
F-box/LRR-repeat protein 12

1

2

High-throughput

0.437

High

1142497

SKI8
Superkiller complex protein 8

1

1

High-throughput

0.437

High

1142507

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.437

High

928053

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

0

High-throughput

0.249

Low

1142461

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

0

High-throughput

0.249

Low

1142465

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.249

Low

1142467

FBX44
F-box only protein 44

1

0

High-throughput

0.249

Low

1142479

RAB30
Ras-related protein Rab-30

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024