Interactor 1: LAT (O43561)
Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38)
Gene: LAT
Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.75 | 0.60 | 0.672 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25402006, 24658140, unassigned2173 |
| Identification Methods | two hybrid, protein complementation assay, affinity chromatography technology, ubiquitin reconstruction, luminescence based mammalian interactome mapping |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0016020 - membrane GO:0043410 - positive regulation of MAPK cascade GO:0045121 - membrane raft |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
