HitPredict

Interactor 1: NHR49 (O45666)
Nuclear hormone receptor family member nhr-49
Gene: nhr-49

Interactor 2: Q9U1R0 (Q9U1R0)
Nuclear Hormone Receptor family
Gene: nhr-243

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.791

Property	Details
Experiments	22511885, 14704431
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 501 Ce			1 424
+	Ce
		220326 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR19_CAEEL (3-424): 1.61e-87: 275: 16.02
+	Ce
		106951 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NH114_CAEEL (15-422): 4.08e-87: 272: 13.23
+	Ce
		220319 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR49_CAEEL (12-424): 8.96e-85: 269: 14.19
+	Ce
		220347 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		Q95Y05_CAEEL (3-414): 7.34e-73: 236: 19.42
+	Ce
		109537 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR66_CAEEL (1-410): 2.95e-43: 162: 17.96
+	Hs
		587112 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		RXRA_HUMAN (3-422): 2.37e-95: 295: 14.38
+	Hs
		587136 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		RXRG_HUMAN (2-422): 1.47e-94: 293: 14.01
+	Hs
		782496 HNF4A_HUMAN (5-495): 7.48e-107: 328: 27.80		HNF4A_HUMAN (10-421): 3.51e-92: 287: 16.99
+	Hs
		500354 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		RARB_HUMAN (7-423): 3.51e-87: 274: 16.08
+	Ce
		106935 H2KZA1_CAEEL (14-483): 6.33e-103: 322: 28.78		NH114_CAEEL (15-422): 4.08e-87: 272: 13.23
+	Mm
		509288 RXRA_MOUSE (1-423): 7.87e-106: 325: 27.66		RARA_MOUSE (4-423): 1.38e-83: 265: 15.74
+	Mm
		659690 RXRA_MOUSE (1-423): 7.87e-106: 325: 27.66		NR1H3_MOUSE (5-420): 7.17e-84: 265: 13.70
+	Hs
		487899 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		RARA_HUMAN (4-423): 1.81e-83: 265: 15.74
+	Hs
		587144 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		NR1H2_HUMAN (5-420): 1.16e-83: 265: 13.44
+	Hs
		587162 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		NR1H3_HUMAN (4-420): 8.18e-84: 265: 13.67
+	Hs
		490049 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		NR2F6_HUMAN (5-421): 5.11e-83: 262: 14.39
+	Hs
		368969 RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66		ESR1_HUMAN (10-422): 6.5e-79: 257: 15.37
+	Ce
		220349 NHR49_CAEEL (1-501): 1.06e-161: 469: 100.00		NHR71_CAEEL (27-113): 1.69e-12: 71.2: 40.23
+	Hs
		782501 HNF4A_HUMAN (5-495): 7.48e-107: 328: 27.80		NR2C2_HUMAN (14-105): 2.32e-12: 70.9: 33.70
+	Mm
		659675 RXRA_MOUSE (1-423): 7.87e-106: 325: 27.66		VDR_MOUSE (6-130): 1.98e-11: 67.4: 33.60