Protein: ZAP70
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)

Gene: ZAP70
Organism: Homo sapiens
Interactions: 73
UniProt ID: P43403

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0001784 - phosphotyrosine residue binding
GO:0002250 - adaptive immune response
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439986

LCK
Tyrosine-protein kinase Lck

7

19

Small-scale

0.954

High

362936

EGFR
Epidermal growth factor receptor

5

20

High-throughput

0.924

High

711272

SHC1
SHC-transforming protein 1

4

20

Small-scale

0.888

High

619005

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

3

20

Small-scale

0.834

High

584488

VAV
Proto-oncogene vav

3

20

Small-scale

0.827

High

641518

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

849064

LCP2
Lymphocyte cytosolic protein 2

2

20

Small-scale

0.778

High

711053

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.768

High

849087

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

20

Small-scale

0.765

High

635832

CD3Z
T-cell surface glycoprotein CD3 zeta chain

20

7

Small-scale

0.761

High

849056

CRK
Adapter molecule crk

2

20

Small-scale

0.755

High

849055

ZAP70
Tyrosine-protein kinase ZAP-70

2

20

Small-scale

0.754

High

849061

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.754

High

651210

CBL
E3 ubiquitin-protein ligase CBL

9

20

Small-scale

0.752

High

849084

DBNL
Drebrin-like protein

1

20

Small-scale

0.747

High

849063

3BP2
SH3 domain-binding protein 2

1

20

Small-scale

0.724

High

849069

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.724

High

849089

ASB3
Ankyrin repeat and SOCS box protein 3

1

14

High-throughput

0.698

High

472022

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

532059

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

849058

DAPK1
Death-associated protein kinase 1

1

20

High-throughput

0.692

High

849072

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

High-throughput

0.692

High

460249

CD3E
T-cell surface glycoprotein CD3 epsilon chain

4

4

Small-scale

0.686

High

220358

LAT
Linker for activation of T-cells family member 1

3

6

Small-scale

0.651

High

410700

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

834152

CSK
Tyrosine-protein kinase CSK

1

20

Small-scale

0.647

High

849068

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

849082

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

16

Small-scale

0.647

High

485967

CD3G
T-cell surface glycoprotein CD3 gamma chain

3

6

Small-scale

0.640

High

849065

CBLB
E3 ubiquitin-protein ligase CBL-B

3

20

Small-scale

0.631

High

362200

ABL1
Tyrosine-protein kinase ABL1

1

19

Small-scale

0.618

High

440432

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

461251

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.618

High

635690

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.618

High

699636

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

849057

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

20

Small-scale

0.618

High

849059

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

20

Small-scale

0.618

High

849066

SLAP1
Src-like-adapter

1

20

Small-scale

0.618

High

849071

RHOH
Rho-related GTP-binding protein RhoH

1

20

Small-scale

0.618

High

849077

SHC3
SHC-transforming protein 3

1

20

Small-scale

0.618

High

849081

SLAP2
Src-like-adapter 2

1

20

Small-scale

0.618

High

849086

GAB2
GRB2-associated-binding protein 2

1

20

Small-scale

0.618

High

407160

CD3D
T-cell surface glycoprotein CD3 delta chain

2

6

Small-scale

0.584

High

849074

TBA1A
Tubulin alpha-1A chain

1

20

Small-scale

0.561

High

849080

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

Small-scale

0.561

High

849075

THMS1
Protein THEMIS

1

1

Small-scale

0.550

High

849070

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

3

High-throughput

0.541

High

590259

MUC1
Mucin-1

1

12

Small-scale

0.536

High

849083

APC11
Anaphase-promoting complex subunit 11

1

0

High-throughput

0.518

High

288368

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

14

Small-scale

0.501

High

421674

A4
Amyloid-beta precursor protein

1

20

High-throughput

0.501

High

849079

FCRL3
Fc receptor-like protein 3

1

20

Small-scale

0.501

High

849076

HAVR2
Hepatitis A virus cellular receptor 2

1

4

Small-scale

0.484

High

849078

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.480

High

275876

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

8

Small-scale

0.479

High

378844

CD4
T-cell surface glycoprotein CD4

1

3

Small-scale

0.479

High

438934

CD5
T-cell surface glycoprotein CD5

1

5

Small-scale

0.479

High

457292

TBB5
Tubulin beta chain

1

17

Small-scale

0.479

High

628347

CD33
Myeloid cell surface antigen CD33

1

19

Small-scale

0.479

High

629630

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

666078

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

5

Small-scale

0.479

High

715994

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

5

Small-scale

0.479

High

761575

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

849060

CXCR4
C-X-C chemokine receptor type 4

1

12

Small-scale

0.479

High

849062

TBA1B
Tubulin alpha-1B chain

1

20

Small-scale

0.479

High

849067

CUL3
Cullin-3

1

5

High-throughput

0.479

High

849088

SIT1
Signaling threshold-regulating transmembrane adapter 1

1

4

Small-scale

0.479

High

353075

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

849073

PEAR1
Platelet endothelial aggregation receptor 1

1

20

Small-scale

0.437

High

230943

TYOBP
TYRO protein tyrosine kinase-binding protein

1

1

Small-scale

0.408

High

849085

CBLC
E3 ubiquitin-protein ligase CBL-C

1

20

Small-scale

0.408

High

328360

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025